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PATHOPHYSIOLOGICAL MECHANISMS OF DEEP VEIN THROMBOSIS
S. Chooklin, S. Chuklin
Saint Paraskeva Medical Center, Lviv, Ukraine
DOI: https://doi.org/10.15407/fz69.06.133
![](/images/cite.png)
Abstract
Deep venous thrombosis is a frequent multifactorial disease
and most of the time is triggered by the interaction between
acquired risk factors, particularly immobility, and hereditary
risk factors such as thrombophilias. The mechanisms
underlying deep venous thrombosis are not fully elucidated;
however, in recent years the role of venous flow, endothelium,
platelets, leukocytes, and the interaction between inflammation
and hemostasis has been determined. Alteration of venous
blood flow produces endothelial activation, favoring the
adhesion of platelets and leukocytes, which, through tissue
factor expression and neutrophil extracellular traps formation,
contribute to the activation of coagulation, trapping more cells,
such as red blood cells, monocytes, eosinophils, lymphocytes.
The coagulation factor XI-driven propagation phase of blood
coagulation plays a major role in venous thrombus growth, but
a minor role in hemostasis. In this work, the main mechanisms involved in the pathophysiology of deep vein thrombosis are
described.
Keywords:
deep vein thrombosis; blood flow; endothelial dysfunction; blood cells.
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