MULTIFUNCTIONAL ACTIVITY OF NUCLEAR PROTEIN AMPHOTERIN AND ITS ROLE IN ENDOTOXEMIA
O.A. Kondratska, N.G. Grushka, V.V. Veshko, S.I. Pavlovych, R.I. Yanchii
Bogomoletz Institute of Physiology of the National Academy
of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz69.06.120
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Abstract
The review summarizes generalizing modern scientific data
on the main functions of the protein HMGB1, and its physiological and pathological roles. Amphoterin is involved in
key processes that ensure the functioning of DNA in the cell
nucleus and plays an important role outside it. HMGB1 has
been implicated in many human inflammatory diseases such
as sepsis, ischemic reperfusion injury, neurological conditions, cardiovascular disease, autoimmune disease, and others.
This manuscript describes the structure and main functions
of HMGB1, discusses the significance of this alarmin as
damage-associated molecular patterns, and analyzes its role
in the development of inflammation and cell death. Special
attention is focused on the role of HMGB1 in the development
of endotoxemia, as well as data on the signaling pathways
involved in its pathogenesis. Information on the results of
studies of the possibility of modulating the activity of this
protein using inhibitors is also considered, since understanding
this may be useful for developing new therapeutic strategies
aimed at treating inflammatory conditions of various origins.
Keywords:
amphoterin; endotoxemia; therapeutic strategies; inflammatory conditions.
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