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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2023; 69(6): 97-107

Stress-induced disorders of reproductive functions

A.G. Reznikov

    SI V.P. Komisarenko Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine


The review provides a pathophysiological analysis of what is currently known about the impact of acute and chronic stress on the functional state of the male and female reproductive systems. The relevance of research on the negative effects of stress on the reproductive system has increased significantly in recent years due to the COVID-19 pandemic and even more so after Russia’s aggression against Ukraine. Stress disrupts gamete maturation, libido, sexual behavior, mating, fertilization, pregnancy and delivery. In the structure of the etiology of these disorders, psycho-social stress prevails. The characteristics of stress-induced disorders of the reproductive system have features depending on the lifestyle of future parents, as well as on the period of life, starting from the embryonic to the end of the reproductive age. The hypothalamicpituitary-adrenocortical and hypothalamic-pituitary-gonadal systems, as well as oxidative-nitrosative stress, play a leading role in the pathogenesis of stress-induced disorders of the reproductive system. Modern data on the pathogenesis of stress-induced reproductive disorders should be the basis of preventive and therapeutic strategies.

Keywords: stress; reproduction; ovaries; testes; hypothalamus; pituitary gland; adrenal glands.


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