Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2002; 48(4): 43-46


Effects ofthermal injure on reactivity of neuroendocrine system

E.F. Barynov E.Ya.Fystal A.E. Barynov N.N. Bondarenko S.V. Zyablintsev

    M.Gorky Medical University, Donetsk


Abstract

To study reactivity of hypothalamo-hypophyseal-adrenal system to stress in patients with thermal skin burns we determined the content of cortisol in blood, chemosensitivity of glucocorticoid receptors on thrombocytes and effects of dexamethasone infusions on these parameters. In patients with normal reactivity of the organism and increased initial level of cortisol its content was shown to be increased by 34.1% in 2-3 hours after infusion of dexamethasone, but it decreased in 5-6 hours and subsequently. In patients with low initial level of cortisol dexamethasone caused prolongation of the hormonal response (the level of cortisol increased by 57.9% in 2-3 hours; by 27.1% in 5-6 hours, and by 16.9% in 24 hours as compared to the initial level), which is a manifestation of its modifying effect on the reactivity of the system to stress. In these patients decrease in chemosensitivity of glucocorticoid receptors should be taken into consideration at analysis of the inflammatory reaction owing to modifying effects of steroid hormones on the cytokine production.

References

  1. Гланц С. Медико-биологическая статистика. Пер.с англ.– М.: Практика, 1998.– 459 с.
  2. Feldman S., Weidenfeld J. Glucocoticoid receptor antagonists in the hippocampus modify the negative feedback following neural stimuli // Brain Res.– 1999.– 821, №1.– P.33-37.
  3. Maccari S., Mormada P., Piazza P.V. et al. Hippocampal type I and type II corticosteroid receptors are modulated by central noradrenergic systems //Psychoneuroendocrinoligy.– 1992.–13, № 2-3.–P.103-112.
  4. Murton S.A., Tan S.T., Prickett T.C., Frampton C., Donald R.A. Hormone responses to stress in patients with major burns // Br. J. Plast. Surg.–1998.– 51, № 5.– Р. 388-392.
  5. Sedowofia K., Barclay C., Quaba A. et al. The systemic stress response to thermal injury in children // Clin. Endocrinol. (Oxf).– 1998.– 49, №3.– Р. 335-341.
  6. Spencer R.L., Kim P.J., Kalman B.A., Cole M.A. Evidence for mineralocorticoid receptor facilitation of glucocorticoid receptor-dependent regulation of hypothalamic-pituitary-adrenal axis activity //Endocrinology.–1998.– 139, № 6.–P.2718-2726.
  7. Wu Y.H. Glucocorticoid receptor (GCR) in canine peripheral lymphocyte during early postburn period // Zhonghua Zheng Xing Shao Shang Wai Ke ZaZhi.– 1992.– 8, № 3.– Р. 225-227, 250.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2018.