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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2023; 69(6): 52-59


О.Ya. Оmelchuk1, D.M. Nozdrenko2, O.P. Motuziuk1,2, K.I. Bogutska2, V.M. Soroсa2, S.V. Prylutska3, A.V. Zholos2

  1. Lesya Ukrainka Volyn National University, Lutsk, Ukraine
  2. Taras Shevchenko National University of Kyiv, Ukraine
  3. National University of Life and Environmental Science of Ukraine, Kyiv, Ukraine


Rhabdomyolysis, as an acute stage of myopathy, causes kidney damage. Literary data indicate that this pathology is caused by the accumulation of muscle breakdown products and is associated with oxidative stress. Therefore, the effect of water-soluble C60 fullerenes (C60), as powerful antioxidants, at different doses of intraperitoneal administration (1 and 2 mg·kg-1) on the development of kidney damage due to the rhabdomyolysis of various severity degrees, which was caused by the intramuscular injection of a 50% glycerol solution into the muscle soleus in doses of 5, 10 and 15 mg·kg-1 was evaluated in the present work. C60 injections at doses of 2 mg·kg-1 have been shown to most effectively increase glomerular filtration rate (GFR) in severe renal failure (by 29, 38 and 51% on the 3rd, 6th and 9th day of the experiment, respectively). Changes in the content of creatine phosphokinase and activity of glutathione peroxidase in the blood of experimental animals are correlated well (r > 0.94) with changes in GFR with the use of C60. This opens up new opportunities in the therapy of pathological conditions of the muscular system, which are caused by rhabdomyolysis, release of labile Fe3+ from damaged muscle fibers and associated oxidative stress.

Keywords: rhabdomyolysis; renal failure; biochemical parameters; muscle soleus; C60 fullerene.


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