THE IMPACT OF WATER-SOLUBLE C60 FULLERENES ON THE COURSE OF RHABDOMYOLYSIS-INDUCED KIDNEY DAMAGE OF VARIOUS SEVERITY DEGREES
О.Ya. Оmelchuk1, D.M. Nozdrenko2, O.P. Motuziuk1,2, K.I. Bogutska2, V.M. Soroсa2, S.V. Prylutska3, A.V. Zholos2
- Lesya Ukrainka Volyn National University, Lutsk, Ukraine
- Taras Shevchenko National University of Kyiv, Ukraine
- National University of Life and Environmental Science of
Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz69.06.052
Abstract
Rhabdomyolysis, as an acute stage of myopathy, causes
kidney damage. Literary data indicate that this pathology is
caused by the accumulation of muscle breakdown products
and is associated with oxidative stress. Therefore, the effect of
water-soluble C60 fullerenes (C60), as powerful antioxidants,
at different doses of intraperitoneal administration (1 and
2 mg·kg-1) on the development of kidney damage due to
the rhabdomyolysis of various severity degrees, which was
caused by the intramuscular injection of a 50% glycerol
solution into the muscle soleus in doses of 5, 10 and 15
mg·kg-1 was evaluated in the present work. C60 injections
at doses of 2 mg·kg-1 have been shown to most effectively
increase glomerular filtration rate (GFR) in severe renal
failure (by 29, 38 and 51% on the 3rd, 6th and 9th day of the
experiment, respectively). Changes in the content of creatine
phosphokinase and activity of glutathione peroxidase in the
blood of experimental animals are correlated well (r > 0.94)
with changes in GFR with the use of C60. This opens up new
opportunities in the therapy of pathological conditions of the
muscular system, which are caused by rhabdomyolysis, release
of labile Fe3+ from damaged muscle fibers and associated
oxidative stress.
Keywords:
rhabdomyolysis; renal failure; biochemical parameters; muscle soleus; C60 fullerene.
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