DETECTION OF ANTIBODIES TO SARS-COV-2 VIRUS IN PATIENTS WITH CORONARY HEART DISEASE AND SYSTEMIC RHEUMATIC DISEASES BEFORE THE ONSET OF THE COVID-19 PANDEMIC
V.M. Kornatskyi, N.O. Ryzhkova, O.M. Parkhomenko, O.M. Lomakovsky, A.M. Dorokhina, Yu.V. Kornatskyi, V.G. Levchenko, A.V. Romanovskyi
SI National Scientific Center M.D. Strazhesko Institute of
Cardiology of the National Academy of Medical Sciences of
Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz69.05.061
Abstract
Seasonal coronaviruses may serve as an informative model
for determining the duration of protection against reinfection during future waves of coronavirus disease. Data from
the literature suggest that ELISA kits designed to detect
antibodies to SARS-CoV-2 may also be sensitive to seasonal
coronaviruses. The aim of our work was to perform a retrospective study to determine the presence of IgG and IgM to
coronaviruses in Ukraine before the COVID-19 pandemic. The
study was conducted on the serum of 321 patients with various
cardiorheumatologic profiles who were treated in a hospital
during 2013-2018. The obtained data indicate the possibility of
cross-immunity among coronaviruses since antibodies to this
virus were present in 3.3% of patients with acute myocardial
infarction, 5.9% with systemic rheumatological diseases, and
27.3% with chronic coronary heart disease.
Keywords:
coronavirus; cardiovascular diseases; antibodies.
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