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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2023; 69(4): 85-91


Submicroscopic changes of periodontal components under experimental periodontitis combined with hypothyroidism

V. Shcherba1, A.E. Demkovych1, A.B. Vorobets1, І.R. Yanchii2

  1. I. Horbachevsky Ternopil National Medical University, Ukraine
  2. State Institution V.P. Komisarenko Institute of Endocrinology and Metabolism National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz69.04.085


Abstract

Endocrine disorders are an extremely urgent medical and social problem of modern society. Changes in the thyroid gland activity cause violations of the regulation of metabolism in periodontal tissues. Expressed clinical signs of periodontal tissues inflammation directly depend on the severity and duration of disorders of the functional state of the thyroid gland. The purpose of this study was to describe the ultrastructural changes of periodontal tissues under the conditions of experimental periodontitis in combination with hypothyroidism. To model periodontitis lipopolysaccharide was injected into the gum tissue of rats. The experimental thyroid gland hypofunction was simulated using intragastrical administration of mercazolyl. To confirm the state of hypothyroidism we determined the content of free thyroxine, free triiodothyronine and thyroid-stimulating hormone. Submicroscopic studies revealed profound destructive-degenerative changes in all components of the periodontium. Changes in periodontal tissues in experimental hypothyroidism are stereotyped: dystrophic, atrophic and destructive changes in parenchymal structures, mucinous edema of the stroma, mild reparative processes. Thus, it can be concluded that during experimental periodontitis in combination with hypothyroidism, there are violations of the functioning of all the components of the vessels of the periodontal microcirculatory channel. This is manifested by damage and deformation of the blood vessel wall with desquamation of the endothelium, edema, thinning of the basement membrane, stasis, thrombosis and spasm. Also, significant destruction and lysis of fibrous structures and components of the connective tissue amorphous substance in the lamina propria of the attached and free part of gums and periodontium are characteristic.

Keywords: periodontitis; hypothyroidism; periodontium; ultrastructural changes

References

  1. Greabu M, Giampieri F, Imre MM, Mohora M, Totan A, Pituru SM, Ionescu E. Autophagy, one of the main steps in periodontitis pathogenesis and evolution. Molecules. 2020;25(18):4338. CrossRef PubMed PubMedCentral
  2. Slots J. Periodontitis: facts, fallacies and the future. Periodontol 2000. 2017;75(1):7-23. CrossRef PubMed
  3. Yi G, Ma Y, Chen Y, Yang X, Yang B, Tian W. A review of the functions of matrix vesicles in periodontal tissues. Stem Cells Dev. 2021;30(4):165-76. CrossRef PubMed
  4. Demkovych A, Hasiuk P, Korobeinikova Y, Shcherba V, Korobeinikov L. Dynamics of changes of c-reactive protein level in blood serum in the development and course of experimental periodontitis and their correction by flavonol. Wiad Lek. 2022;75(2):451-55. CrossRef PubMed
  5. Redman RS, Bayley NC, Nylén ES. Salivary and serum biomarkers of inflammation in a man with metastatic medullary thyroid carcinoma and hyperreactive gingiva: a fourteen year odyssey. Biotech Histochem. 2019;94(6):38997. CrossRef PubMed
  6. Wiersinga WM. Therapy of endocrine disease: T4 + T3 combination therapy: is there a true effect? Eur J Endocrinol. 2017;177(6):287-96. CrossRef PubMed
  7. Foda DS, Shams SG. A trial for improving thyroid gland dysfunction in rats by using a marine organism extract. Braz J Biol. 2021;81(3):592-600. CrossRef PubMed
  8. Mat Ali MH, Tuan Ismail TS, Wan Azman WN, Yaacob NM, Yahaya N, Draman N, Wan Mohamed WMI, Abdullah MS, Ibrahim HA, Wan Nik WNFH, Mohamed M. Comparison of vitamin D levels, bone metabolic marker levels, and bone mineral density among patients with thyroid disease: a cross-sectional study. Diagnostics (Basel). 2020;10(12):1075. CrossRef PubMed PubMedCentral
  9. Milosavljevic A, Wolf E, Englander M, Stavropoulos A, Götrick B. The lived experience of performing a periodontal treatment in the context of general dentistry. BDJ Open. 2021;7(1):7. CrossRef PubMed PubMedCentral
  10. Avetisyan A, Markaryan M, Rokaya D, Tovani-Palone MR, Zafar MS, Khurshid Z, Vardanyan A, Heboyan A. Characteristics of periodontal tissues in prosthetic treatment with fixed dental prostheses. Molecules. 2021;26(5):1331. CrossRef PubMed PubMedCentral
  11. Koman A, Näsman P, Discacciati A, Ekbom A, Nilsson IL, Sandborgh-Englund G. Increased risk for tooth extraction in primary hyperparathyroidism and hypercalcemia: a population study. Clin Oral Invest. 2020;24(8):2755-61. CrossRef PubMed
  12. Bandrivsky Y, Bandrivska O, Malko N, Posolenyk L, Vydoinyk O, Iskiv M. The effectiveness of the use of polypeptide drugs and their effect on the metabolic parameters of oral fluid in patients with generalized periodontitis in depending on blood type. Pharmacia. 2022;69(2):429-35. CrossRef
  13. Mekhno N, Yaremchuk O. Impact of nitric oxide synthesis modulators on the state of humoral immune system in experimental antiphospholipid syndrome. Pharmacia. 2023;70(1):9-14. CrossRef
  14. Lenartova M, Tesinska B, Janatova T, Hrebicek O, Mysak J, Janata J, Najmanova L. The oral microbiome in periodontal health. Front Cell Infect Microbiol. 2021;11:629723. CrossRef PubMed PubMedCentral
  15. Morais A, Resende M, Pereira J. Thyroiditis and periodontal disease: A narrative review. J. Acta Med Port. 2016;29(10):651-57. CrossRef PubMed
  16. Bilash SM, Pronina OM, Koptev MM. Comprehensive morphological studies as an intergal part of modern medical science. Literature review. Visn Probl Bioloh Med. 2019;2(151):20-3. CrossRef
  17. Yussif NM, El-Mahdi FM, Wagih R. Hypothyrodism as a risk factor of periodontitis and its relation with vitamin D deficiency: mini-review of literature and a case report. Clin Cases Miner Bone Metab. 2017;14(3):312-16. CrossRef PubMed PubMedCentral
  18. Demkovych AYe, Bondarenko YuI, Fastovets OO, Hrad AO, Hasiuk PA, Denefil OV. State of collagenolysis in experimental periodontitis of bacterial-immune genesis and its correction with flavonol. Med Perspekt. 2021;26(2):26-32. CrossRef
  19. Demkovych A, Shcherba V, Yaremchuk O, Stoikevych H, Machogan V, Luchynskyi V. Effects of flavonol quercetin on syndrome of endogenous intoxication in experimental periodontitis. Pharmacia. 2021;68(3):627-32. CrossRef
  20. Bandrivsky Yu, Bandrivska O, Bandrivska N, Bedenyuk O, Piasetska L, Dutko K. The effect of complex treatment on some hematological and hemostasiological indicators during the treatment of generalized periodontitis in patients with different blood group affiliation. Pharmacia. 2022;69(4):1027-33. CrossRef
  21. Imran M, Mehmood Z, Baloch MN, Altaf S. Endoscopic thyroid lobectomy vs Conventional open thyroid lobectomy. Pak J Med Sci. 2020;36(4):831-35. CrossRef PubMed PubMedCentral
  22. Aldulaijan HA, Cohen RE, Stellrecht EM, Levine MJ, Yerke LM. Relationship between hypothyroidism and periodontitis: A scoping review. Clin Exp Dent Res. 2020;6(1):147-57. CrossRef PubMed PubMedCentral
  23. Bhankhar RR, Hungund S, Kambalyal P, Singh V, Jain K. Effect of nonsurgical periodontal therapy on thyroid stimulating hormone in hypothyroid patients with periodontal diseases. Ind J Dent Res. 2017;28(1):16-21. CrossRef PubMed
  24. Rahangdale SI, Galgali SR. Periodontal status of hypothyroid patients on thyroxine replacement therapy: A comparative cross-sectional study. J Ind Soc Periodont. 2018;22(6):535-40. CrossRef PubMed PubMedCentral
  25. Keong JY, Low LW, Chong JM, Ong YY, Pulikkotil SJ, Singh G, Nagendrababu V, Banavar SR, Khoo SP. Effect of lipopolysaccharide on cell proliferation and vascular endothelial growth factor secretion of periodontal ligament stem cells. Saudi Dent J. 2020;32(3):148-54. CrossRef PubMed PubMedCentral

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