Submicroscopic changes of periodontal components under experimental periodontitis combined with hypothyroidism
V. Shcherba1, A.E. Demkovych1, A.B. Vorobets1, І.R. Yanchii2
- I. Horbachevsky Ternopil National Medical University, Ukraine
- State Institution V.P. Komisarenko Institute of Endocrinology and Metabolism National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz69.04.085
Abstract
Endocrine disorders are an extremely urgent medical and social problem of modern society. Changes in
the thyroid gland activity cause violations of the regulation of metabolism in periodontal tissues. Expressed
clinical signs of periodontal tissues inflammation directly depend on the severity and duration of disorders
of the functional state of the thyroid gland. The purpose of this study was to describe the ultrastructural
changes of periodontal tissues under the conditions of experimental periodontitis in combination with
hypothyroidism. To model periodontitis lipopolysaccharide was injected into the gum tissue of rats. The
experimental thyroid gland hypofunction was simulated using intragastrical administration of mercazolyl.
To confirm the state of hypothyroidism we determined the content of free thyroxine, free triiodothyronine and
thyroid-stimulating hormone. Submicroscopic studies revealed profound destructive-degenerative changes
in all components of the periodontium. Changes in periodontal tissues in experimental hypothyroidism are
stereotyped: dystrophic, atrophic and destructive changes in parenchymal structures, mucinous edema of
the stroma, mild reparative processes. Thus, it can be concluded that during experimental periodontitis
in combination with hypothyroidism, there are violations of the functioning of all the components of the
vessels of the periodontal microcirculatory channel. This is manifested by damage and deformation of
the blood vessel wall with desquamation of the endothelium, edema, thinning of the basement membrane,
stasis, thrombosis and spasm. Also, significant destruction and lysis of fibrous structures and components
of the connective tissue amorphous substance in the lamina propria of the attached and free part of gums
and periodontium are characteristic.
Keywords:
periodontitis; hypothyroidism; periodontium; ultrastructural changes
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