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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2023; 69(4): 40-44


A.V. Savotchenko1, E.V. Isaeva2, D.S. Isaev1

  1. Bogomoletz Institute of Physiology of National Academy of Science of Ukraine, Kyiv, Ukraine
  2. Medical College of Wisconsin, Milwaukee, USA


Neuraminidase (NEU) is the key enzyme that cleaves negatively charged sialic acids of the cell surface. The results of numerous studies suggest that an imbalance in NEU metabolism due to various pathological conditions significantly affects nervous activity. Thus, it was shown that downregulation of NEU leads to such morphological changes as accumulation of sialic acid residues in the extracellular space and synaptogenesis. However, the functional ability of newly formed synapses remains unclear. Using the specific blocker 2-deoxy-2,3-dehydro-N-acetylneuraminic acid (NADNA), we examined the effect of NEU inhibition on synaptic efficacy in the hippocampal CA3-CA1 neuronal network. The significant increase in the amplitude of synaptic responses due to NEU blockage was accompanied by the decrease in their variability, which indicates the enhanced functional excitatory synaptic connectivity in the hippocampal CA3-to-CA1 network.

Keywords: neuraminidase blocker; polysialic acids; hippocampus; synaptogenesis; synaptic efficacy.


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