MARKERS OF PSYCHO-EMOTIONAL STRESS IN WOMEN OF THE KYIV REGION THE RUSSIAN-UKRAINIAN WAR
V.B. Shatilo, I.A. Antoniuk-Shcheglova, O.V. Bondarenko, S.S. Naskalova, А.V. Pisaruk, L.V. Mekhova, A.N. Ustymenko
D.F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz69.04.003
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Abstract
War-related stress (WSR) leads to disruption of vital physiological functions, which can accelerate the development of
age-related pathology and early mortality. Therefore, the study
of the impact of SPV on the functioning of various body systems requires an in-depth analysis. The purpose of the study
is to assess the level of psycho-emotional stress, anxiety, and
depression and to investigate their influence on indicators
of endothelial function, lipid, carbohydrate metabolism,
autonomic nervous regulation of the cardiovascular system)
in women of the Kyiv region during the Russian-Ukrainian
war. 56 women aged 30-78 were examined (average age -
53.45 ± 1.6 years), who had been in the Kyiv region without
permission since the beginning of the Russian-Ukrainian
war (February 24, 2022). The control group consisted of 79
women aged 29-85 years, (average age - 56.46 ± 1.44 years),
who were examined before the start of the Russian-Ukrainian
war in 2018-2021. Anthropometric parameters, fasting
plasma glucose level and standard oral glucose tolerance
test (OGTT), serum lipid concentration, plasma cortisol
level were determined. The function of the endothelium of
microvessels was studied by the method of laser Doppler
flowmetry in a sample with reactive post-occlusion hyperemia,
the state of autonomic regulation of the cardiovascular
system by the method of heart rhythm variability analysis.
Psychoemotional state using the PLC-5 scale, Beck depression
scale, Spielberger-Hanin test, the state of cognitive function
was studied using the Montreal Cognitive Assessment (MoCA)
A statistically significant increase in the level of cortisol, as
an important marker of WSR, was revealed, compared to the
control group. Excessive psycho-emotional stress of the body
during the war is also evidenced by the predominance of the sympathetic link of autonomous nervous regulation in women.
The development of endothelial dysfunction and the negative
impact of WSR on lipid and carbohydrate metabolism were
confirmed, which was combined with a decrease in mental
performance indicators, an increase in the levels of personal
and situational anxiety, and depression. An increase in the
level of cortisol and the activity of the sympathetic link of the
autonomic nervous system indicates the presence of chronic
psychoemotional stress, which increases the levels of anxiety
and depression, reduces the mental performance of women in
war conditions and leads to the development of endothelial
dysfunction, disorders of lipid and carbohydrate metabolism.
Keywords:
psychoemotional stress; cortisol; heart rhythm variability; blood glucose and lipids; microvascular endothelium function
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