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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2023; 69(3): 99-105

Influence of bacterial lipopolysaccharide on the degradation of the components of the extracellular matrix of rat biceps femoris muscle during high fructose diet-induced metabolic syndrome

O.Y. Akimov, A.O. Mykytenko, A.V. Mischenko, V.O. Kostenko

    Poltava State Medical University, Ukraine


Metabolic syndrome is an epidemic of non-infectious origin, which is associated with the consumption of a large amount of high-calorie food and a sedentary lifestyle. It is not excluded that bacterial lipopolysaccharides (LPS) may enter the body during metabolic syndrome. The purpose of this work is to study the combined effect of bacterial lipopolysaccharide and high fructose diet on the concentration of glycosaminoglycans and their individual fractions, the content of free L-oxyproline and sialic acids in rat biceps femoris muscle. Bacterial LPS was injected intraperitoneally at a dose of 0.4 μg/kg. Metabolic syndrome was modelled by using 20% fructose solution as only source of drinking water. In the test group of animals total concentration of glycosaminoglycans increased by 22.53%, the heparin-heparan and keratan-dermatan fraction concentrations raised by 26.18 and 35.91%, but concentration of the chondroitin fraction did not change compared to the control. The concentrations of free L-oxyproline and sialic acids increased by 120.71 and 156.78%, respectively. Thus, high fructose diet, stimulation of the organism with bacterial lipopolysaccharide and their combination lead to increased degradation of glycoproteins and proteoglycans and intensify collagenolysis in the biceps femoris muscle of rats.

Keywords: metabolic syndrome; bacterial lipopolysaccharide; L-oxyproline; glycosaminoglycans; sialic acids; biceps femoris.


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