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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2023; 69(3): 3-9


High-energy photons vs protons in their action on vascular function in rats

A.I. Soloviev1, I.V. Ivanova1, A.S. Khromov1, N.V. Dobrelia1, T.V. Novokhatska1, K.S. Klymenko1, I.L. Monchak1, A.A. Pavlova1, A.М. Valkov2, L.N. Mikhailov2, A.I. Piskarev2, P. Nolan3, P. Pusa3

  1. Institute of Pharmacology and Toxicology, National Academy of Medical Science, Kyiv, Ukraine
  2. Institute for Nuclear Researches, National Academy of Sciences, Kyiv, Ukraine
  3. University of Liverpool, UK
DOI: https://doi.org/10.15407/fz69.03.003

Abstract

The goal of this work was to compare the effects of a photon (PTI) and proton/hadron (HTI) irradiation on rat’s cardiovascular system. Cardiovascular functions were studied in rats after PTI and HTI impact in the equivalent total absorbed dose of 6 Gy. Photons were delivered using 60Co gamma-rays (0.8 Gy min-1). The particle irradiation was done by using a 9,6×10-12 J proton beam accelerated in the U-240 isochronous cyclotron. Both PTI and HTI decreased the acetylcholine-induced relaxation in rat’s aorta smooth muscle (SM) and outward potassium currents in aortic SM cells on the 9th day post-irradiation but HTI appeared to produce a more profound effect. HTI had no significant effect on systolic blood pressure (SBP) in rats while PTI produced clearly defined systemic hypertension. HTI, unlike PTI, significantly increased the left ventricle pressure in Langendorff - perfused rat’s heart. Thus, the biological effects of PTI and HTI on rat’s aorta endothelium-dependent relaxation and net potassium currents in the SM cells appear to be similar, although the effects of HTI are more pronounced. However, PTI, unlike HTI, produced significant systemic hypertension.

Keywords: photon and proton irradiation; cardiovascular function; potassium currents; endotheliumdependent relaxation.

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