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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2002; 48(4): 14-18


Correlation between gaseous exchange rate, body temperature,and mitochondrial protein content in liver of mice

Muradjan Kh. Utko N. Mozzhukhina T.G. Pishel I.N. Litoshenko A.Y. Bezrukov V.V.Fraifeld V.

    Institute of Gerontology Academy of MedicalSciences of Ukraine, Kiev;Institute Ben-Gurion in Negev, Ber-Sheva, Israel


Abstract

Correlative and regressive relations between the gaseous exchange, thermoregulation and mitochondrial protein content were analyzed by two- and three-dimensional statistics in mice. It has been shown that the pair wise linear methods of analysis did not reveal any significant correlation between the parameters under exploration. However, it became evident at three-dimensional and non-linear plotting for which the coefficients of multivariable correlation reached and even exceeded 0,7-0,8. The calculations based on partial differentiation of the multivariable regression equations allow to conclude that at certain values of Vo2, Vсo2 and body temperature negative relations between the systems of gaseous exchange and thermoregulation become dominating.

References

  1. Иванов К.П. Биоэнергетика и температурный гомеостазис. - Л.: Наука. 1972. – С. 172.
  2. Тимченко А.Н., Мозжухина Т.Г., Мурадян Х.К. Влияние гипергравитацион-ного стресса на выживаемость, газообмен, терморегуляцию, синтез РНК и белка у мышей разного возраста // Пробл. старения и долголетия. -1996. – 6, N 2. - С.145-150.
  3. Berner N.J. Oxygen consumption by mitochondria from an endotherm and an ectotherm // Comp. Biochem. and Physiol. – 1999. –124, N 1.- P.25-31.
  4. Cypser J.R., Johnson T.E. Multiple stressors in Caenorabditis elegans induce stress hormesis and extended longevity // J. Gerontol. –2002.- 57, N 3.- P.B109-B114.
  5. Echtay K.S., Roussel D., St-Pierre J. et al. Superoxide activates mitochondrial uncoupling proteins// Nature.- 2002.- 415, N 6867.-P. 96-99.
  6. Ferguson R.A., Ball D., Sargeant A.J. Effectof muscle temperature on rate of oxygen up-take during exercise in humans at different contraction frequencies// J. Exp. Biol.- 2002.- 205,N 7.- P. 981-987.
  7. Frolkis V.V., Muradian Kh.K. Life span prolongation // Boca Raton: CRC Press, 1991. –р. 425.
  8. Jentjens R.L., Wagenmakers A.J., Jeukendrup A.E.Heat stress increases muscle glycogen use but reduces the oxidation of ingested carbohydrates during exercise// J. Appl. Physiol.- 2002.- 92, N 4.-P.1562-1572.
  9. 9. Lowry O.H., Rosenbrough N.H., Farr A.L., RandallJ.R. Protein measurement with the Folin phenol reagent// J.Biol. Chem. – 1951.-193.- P. 265-275.
  10. 10. Vercesi A., Reynafarje B., Lehninger A.L. Stechiometry of H+ ejection and Ca2+ uptake coupled to electron transport in rat heart mitochondria//J.Biol. Chem.- 1978.- 253.- P.6379-6385.

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