Intermittent pneumatic compression (IPC) widely used in the therapy of preventing the formation of blood clots, improving the oxygenation of peripheral tissues. IPC is an established method in the therapy of post-operative recovery and in geriatrics and sports medicine. The purpose of our study was to determine functional changes in heart rate variability (HRV) and peripheral hemodynamics during exposure to lowintensity IPC depending on different types of regulation of the autonomic nervous system. We investigated 62 participants in age of 18-22 years. Testing sessions that included pressure of 40 mmHg and 20-minute period of temporary occlusion of the lower extremities was performed by intermittent pneumatic compression with Recovery Pump PRX device (“Mego Aftek AC Ltd”, Israel). During the procedure exposure and recovery period, arterial blood pressure was recorded with Korotkov’s auscultative method by mercury tonometer (“Dr. Frei”A-10, Switzerland). Heart Rate was monitored using a Cardio Trainer Polar H9 (“Polar Electro Oy”, Finland). For monitoring hemodynamic changes, impedance cardiography (ICG) method (“ХАІ-medica”, Kharkiv, Ukraine) was applied by 15 s. Based on the spectrum power values in the range of 0.15–0.4 (HFnorm), 3 groups of volunteers were determined using sigma deviations. Group 1 included 29 volunteers with an advantage of the sympathetic link of regulation of the autonomic nervous system (the background HFnorm was less than 40 nu). Group 2 included 19 persons with a normotonic type of autonomic nervous system regulation (HFnorm from 40 to 60 nu). Group 3 included 14 individuals with predominance of the parasympathetic link of the autonomic nervous system (HFnorm above 60 nu). In conclusion, IPC treatment in groups 1 and 2 inhibited the sympathetic activation, increased the blood flow in the large femoral arteries and tone of small arteries. In group 3, the blood outflow from the lower extremities was predominance, the blood flow volume and speed decreased. Therefore, we conclude effectivity of the low intensity IPC using. Also, HRV and peripheral hemodynamics depend on the types of regulation of the autonomic nervous system.