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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2023; 69(1): 68-76


V.I. Kravchenko1, A.V. Venhreniuk2, A.O. Cherninskyi2

  1. Taras Shevchenko National University of Kyiv, Ukraine
  2. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine


Acid-sensing ion channels (ASICs) are ionotropic receptors that generate an inward cationic current in response to a relatively rapid drop in extracellular pH. They were found in the membranes of neurons and glial cells. In the peripheral nervous system, ASICs are involved, in particular, in nociception. More intriguing is the role of these channels in the functioning of the central nervous system. They are widely expressed in brain regions involved in systemic, integrative functions. This review is devoted to the role of ASICs in the implementation of higher-order information processing like emotional regulation, fear extinction, spatial memory, and different forms of learning.

Keywords: acid-sensing ion channels; anxiolytic action; spatial memory; associative learning; fear; addiction.


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