EVALUATION OF THE EFFICIENCY OF THE NEUROPROTECTIVE DRUGS AFTER PRENATAL HYPOXIA
I.F. Belenichev1, O.G. Aliyeva1, L.M. Gunina2, N.V. Bukhtiyarova1
- Zaporizhzhia State Medical University, Ukraine
- National University of Physical Education and Sport of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz69.01.043
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Abstract
We studied the effect of angiolin, thiotriazoline, tamoxifen,
glutaredoxin, cerebrocurin, mildronate, nicomex, L-arginine,
HSF-1, and the reference drug piracetam on molecular markers
of neurodestruction/neuroprotection in a model of chronic
hemic prenatal hypoxia (PH) for experimentally substantiate
the prospects for further study of these drugs as components
of complex treatment of central nervous system damage at
prenatal hypoxic. The concentration of HSP70, metalloproteinase-8 (MPP-8), and nitrotyrosine in the blood plasma of rats on
days 30 and 60 after PH was studied by enzyme immunoassay.
It has been established that chronic PH leads to an increase
in the concentration of nitrotyrosine, MMP8, and inhibition
of the synthesis of HSP70, which indicates a violation of the
mechanisms of neuroprotection/neurodestruction processes
regulation. Course injections of the studied preparations led
to an increase in the level of HSP70 in the blood serum of
animals and a decrease in the concentration of nitrotyrosine
and MPP-8 with a prolonged effect. Cerebrocurin (150 mg/
kg), Angiolin (50 mg/kg), HSF-1 (50 mg/kg) and Glutaredoxin
(200 μg/kg) most actively affected the parameters of the studied
molecular markers, so they can be considered as promising
neuroprotective agents means in complex therapy after PH.
Keywords:
experimental prenatal hypoxia; central nervous system; neuroprotection; HSP70; HSP70 modulators.
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