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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2023; 69(1): 43-53


I.F. Belenichev1, O.G. Aliyeva1, L.M. Gunina2, N.V. Bukhtiyarova1

  1. Zaporizhzhia State Medical University, Ukraine
  2. National University of Physical Education and Sport of Ukraine, Kyiv, Ukraine


We studied the effect of angiolin, thiotriazoline, tamoxifen, glutaredoxin, cerebrocurin, mildronate, nicomex, L-arginine, HSF-1, and the reference drug piracetam on molecular markers of neurodestruction/neuroprotection in a model of chronic hemic prenatal hypoxia (PH) for experimentally substantiate the prospects for further study of these drugs as components of complex treatment of central nervous system damage at prenatal hypoxic. The concentration of HSP70, metalloproteinase-8 (MPP-8), and nitrotyrosine in the blood plasma of rats on days 30 and 60 after PH was studied by enzyme immunoassay. It has been established that chronic PH leads to an increase in the concentration of nitrotyrosine, MMP8, and inhibition of the synthesis of HSP70, which indicates a violation of the mechanisms of neuroprotection/neurodestruction processes regulation. Course injections of the studied preparations led to an increase in the level of HSP70 in the blood serum of animals and a decrease in the concentration of nitrotyrosine and MPP-8 with a prolonged effect. Cerebrocurin (150 mg/ kg), Angiolin (50 mg/kg), HSF-1 (50 mg/kg) and Glutaredoxin (200 μg/kg) most actively affected the parameters of the studied molecular markers, so they can be considered as promising neuroprotective agents means in complex therapy after PH.

Keywords: experimental prenatal hypoxia; central nervous system; neuroprotection; HSP70; HSP70 modulators.


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