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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2022; 68(5): 3-9


THE STATE OF LONG-TERM AUTOIMMUNE AND INFLAMMATORY REACTIONS AFTER COVID-19

M.I. Lisyany, L.M. Belskaya, A.I. Klyuchnikova, E.P. Krasilenko

    SI “Institute of Neurosurgery of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz68.05.003

Abstract

The purpose of this work was a comparative study of the state of inflammatory reactions and the level of autoantibodies to neuroantigens in COVID-19 previously infected and vaccinated persons. People who have experienced a COVID-19 infection had an increased level of CRP, medium-mass molecules, in their blood serum. This indicates the persistence of a long-term inflammatory reaction after the infection. The level of autoantibodies to neuroproteins in blood sera was increased both in the groups of COVID-19 previously infected and vaccinated patients in comparison with persons who have not undergo the disease. This indicates the activation of humoral neuroautoimmune reactions, which can lead to the activation and development of progressive neurological complications in a remote period after infection. The level of anti-covid antibodies was 2-3 times higher in vaccinated than in COVID-19 previously infected persons, in the last group both high and low titers of antibodies were registered. This indirectly indicates possible re-infection and the need to vaccinate persons who already had experienced the infection. Subjects who have not suffered from COVID-19 show lower signs of intoxication, inflammation, and levels of neuroautoantibodies occurred if compare to other groups. In addition, the titer of specific anticovid antibodies was significantly low; this indicates a lack of humoral immunity to the COVID-19 virus. The reasons and mechanisms of such a “resistance” to infection are unclear and represent a certain scientific and practical interest for further study.

Keywords: COVID-19-infection; inflammation; neuroautoimmune reactions

References

  1. Lukiw W, Pogue A, Hill J. SARS-CoV-2 infectivity and neurological targets in the brain. Cell Mol Neurobiol. 2020;1-8(10):1007. CrossRef PubMed PubMedCentral
  2. Paniz-Mondolfi A, Bryce C, Grimes Z, Gordon RE, Reidy J, Lednicky J, et al. Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). J Med Virol. 2020;92(7):699-702. CrossRef PubMed PubMedCentral
  3. Kornatskyi V, Ryzhkova O, Gavrilenko T, Dorokhina A, et al. IgG, IgM and neutralizing antibodies to SARS-COV-2 in medical workers during the year (2020-2021) before the start of mass vaccination. Fiziol Zh. 2022;68(3):44-50. CrossRef
  4. Matias-Guiu J, Gomez-Pinedo U, Montero-Escribano P, Gomez-Iglesias P, Porta-Etessam J, Matias-Guiu J. Should we expect neurological symptoms in the SARSCoV-2 epidemic? Neurologia. 2020;35(3):170. CrossRef PubMedCentral
  5. Yang N, Shen H-M. Targeting the endocytic pathway and autophagy process as a novel therapeutic strategy in COVID-19. Int J Biol Sci. 2020;16(10):1724-31. CrossRef PubMed PubMedCentral
  6. Sanclemente-Alaman I, Moreno-Jiménez L, Benito-Martín M, Canales-Aguirre A, Matías-Guiu J, Matías-Guiu J, et al. Experimental models for the study of central nervous system infection by SARS-CoV-2. Front Immunol. 2020;(11):2163. CrossRef PubMed PubMedCentral
  7. Bullen C, Hogberg H, Bahadirli-Talbott A, Bishai W, Hartung T, Keuthan C, et al. Infectability of human brain sphere neurons suggests neurotropism of SARS-CoV-2. 2020;37(4):665-71. CrossRef PubMed
  8. Iadecola C, Anrather J, Kamel H. Effects of COVID-19 on the nervous system. Cell. 2020;183(1):16-27. CrossRef PubMed PubMedCentral
  9. Kim W, Corey S, Alvarez X, Williams K. Monocyte/ macrophage traffic in HIV and SIV encephalitis. J Leuk Biol. 2003;74(5):650-6. CrossRef PubMed
  10. Lisyany N. COVID-19 infection and autoimmune reactions. Fiziol Zh. 2022;68(1):87-92. [Ukrainian]. CrossRef
  11. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with Coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020;77(6):683-90. CrossRef PubMed PubMedCentral
  12. Baig A, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the CNS: Tissue distribution, host-virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci. 2020;11(7):995. CrossRef PubMed PubMedCentral
  13. Yavarpour-Bali H, Ghasemi-Kasman M. Update on neurological manifestations of COVID-19. Life Sci. 2020;257:118063. CrossRef PubMed PubMedCentral
  14. 14.Zubair A, McAlpine L, Gardin T, Farhadian S, Kuruvilla D, Spudich S. Neuropathogenesis and neurologic manifestations of the coronaviruses in the age of Coronavirus disease 2019: A Review. JAMA Neurol. 2020;77(8):1018-27. CrossRef PubMed PubMedCentral
  15. Iadecola C, Anrather J, Kamel H. Effects of COVID-19 on the nervous system. Cell. 2020;183(1):16-27. CrossRef PubMed PubMedCentral
  16. Dey J, Alam MT, Chandra S, Gupta J, Ray U, Srivastava AK, et al. Neuroinvasion of SARS-CoV-2 may play a role in the breakdown of respiratory center of the brain. J Med Virol. 2020;1-8. CrossRef PubMed
  17. Miner J, Diamond M. Mechanisms of restriction of viral neuroinvasion at the blood-brain barrier. Curr Opin Immunol. 2016;(38):18-23. CrossRef PubMed PubMedCentral
  18. Desforges M, Miletti TC, Gagnon M, Talbot PJ. Activation of human monocytes after infection by human coronavirus 229E. Virus Res. 2007;130(1):228-40. CrossRef PubMed PubMedCentral
  19. Barrantes F. Central nervous system targets and routes for SARS-CoV-2: current views and new hypotheses. ACS Chem Neurosci. 2020;11(18):2793-803. CrossRef PubMed PubMedCentral
  20. Yachou Y, El Idrissi A, Belapasov V, Ait Benali S. Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients. Neurol Sci. 2020;41(10):2657-69. CrossRef PubMed PubMedCentral
  21. Lisyany N. Immunology and immunotherapy of multiple sclerosis. Kyiv. 2003.
  22. Frimel G. Immunological methods. Medicine. 1987.
  23. Gavrilov V, Bidula M, Furmanchuk D, Konev S, Aleinikova V. Evaluation of intoxication of the body by the imbalance between the accumulation and binding of toxins in the blood plasma. Clin Lab Diagn. 1999;(2):13-5.

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