INTENSITY OF FREE RADICAL PROCESSES IN RAT SKELETAL MUSCLES UNDER THE CONDITIONS OF DIFFERENT DIETARY SUPPLY WITH NUTRIENTS
O.M. Voloshchuk, Н.P. Kopylchuk
Yuriy Fedkovych Chernivtsi National University, Ukraine
DOI: https://doi.org/10.15407/fz68.04.048

Abstract
The intensity of free-radical processes in the skeletal muscles
of rats at different dietary supply with protein and sucrose
was studied. It has been established that the most pronounced
intensification of free radical processes in the mitochondria
of skeletal muscles is found in animals kept on a low-protein/
high-sucrose diet. In particular, the generation of superoxide
anion-radical increases more than 5,3-fold and the generation
of hydroxyl radical more than 3,2-fold compared with the
control, more than a 14,3-fold increase in the carbonyl
derivatives levels, and also decreases by three times in the
free protein SH-groups levels against the background of a
1,7-fold decrease in catalase activity. It has been shown
that excessive consumption of sucrose is a critical factor
influencing the intensity of free radical processes in skeletal
muscle mitochondria. The detected changes can be considered
as prerequisites for skeletal muscle dysfunction under the
conditions of nutrient imbalance.
Keywords:
nutrients; skeletal muscles; reactive oxygen species; oxidative modification of proteins; antioxidant enzymes.
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