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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2022; 68(4): 48-56


O.M. Voloshchuk, Н.P. Kopylchuk

    Yuriy Fedkovych Chernivtsi National University, Ukraine


The intensity of free-radical processes in the skeletal muscles of rats at different dietary supply with protein and sucrose was studied. It has been established that the most pronounced intensification of free radical processes in the mitochondria of skeletal muscles is found in animals kept on a low-protein/ high-sucrose diet. In particular, the generation of superoxide anion-radical increases more than 5,3-fold and the generation of hydroxyl radical more than 3,2-fold compared with the control, more than a 14,3-fold increase in the carbonyl derivatives levels, and also decreases by three times in the free protein SH-groups levels against the background of a 1,7-fold decrease in catalase activity. It has been shown that excessive consumption of sucrose is a critical factor influencing the intensity of free radical processes in skeletal muscle mitochondria. The detected changes can be considered as prerequisites for skeletal muscle dysfunction under the conditions of nutrient imbalance.

Keywords: nutrients; skeletal muscles; reactive oxygen species; oxidative modification of proteins; antioxidant enzymes.


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