Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2022; 68(4): 28-32


E.O. Asanov, A.V. Gavalko, G.V. Duzhak, S.S. Naskalova, І.А. Antonyuk-Shcheglova, V.B. Shatilo

    D. F. Chebotarev Institute of Gerontology of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine


The peculiarities of microcirculation and vasomotor function of the endothelium and their relationship with resistance to hypoxia in the elderly with impaired glucose tolerance were studied. It has been shown that in the elderly with impaired glucose tolerance, skin microcirculation and vasomotor function of the endothelium are reduced when breathing air. An inverse correlation has been established between disorders of carbohydrate metabolism, the state of skin microcirculation and vasomotor function of the endothelium. The connection between the shift of blood saturation under hypoxic load and indicators of microcirculation and vasomotor function of the endothelium in the elderly with both impaired and preserved glucose tolerance. But in the elderly with impaired glucose tolerance, the strength of these connections is greater.

Keywords: impaired glucose tolerance; microcirculation; vascular endothelial function; resistance to hypoxia; old age.


  1. Strain WD, Paldanius PM. Diabetes, cardiovascular disease and the microcirculation. Cardiovasc Diabetol. 2018;17(1):57-67. CrossRef PubMed PubMedCentral
  2. Korkushko OV, Asanov EO, Pisaruk AV, Chizhova VP, Chebotarev ND. Age features of endothelial function and microcirculation under hypoxic stress. Circulat Hemostas. 2007;2:15-9. [Russian].
  3. McMillan DE. Development of vascular complications in diabetes. Vasc Med. 1997;2(2):132-42. CrossRef PubMed
  4. Bregovsky VB, Karpova IA, Alekseeva ES. Disturbances of skin microcirculation in lower extremities in diabetes mellitus:a pathophysiological phenomenon or an object for therapy? Diabet Mellitus. 2011;14(3):49-53. [Russian]. CrossRef
  5. He ZZ, Ma SQ, Deng L, Wang H, Li XH, Xu Y. Microcirculation characteristics and humoral factors of healthy people from different populations at high altitude (4 100 m). Sheng li xue bao [Acta physiologica Sinica]. 2021;73(6):917-25.
  6. Ditzel J. The problems of tissue oxygenation in diabetes mellitus. III. The «three-in-one concept» for the development of diabetic microangiopathy and a rational approach to its prophylaxis. Acta Med Scand Suppl. 1975;578:69-83. CrossRef
  7. Jin KA. microcirculatory theory of aging. Aging Dis. 2019;10(3):676-683. CrossRef PubMed PubMedCentral
  8. American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2021. Diabetes Care. 2021;44(1):S15-S33. CrossRef PubMed
  9. Korkushko OV, Asanov EO, Pisaruk AV, Chebotarev ND. Changes in ventilation during hypoxia in patients with manifestation and accelerated aging of the respiratory system. Ukr Pulmonol Zh. 2009;3:33-5. [Russian]. CrossRef
  10. Duzhak GV, Lishnevskaya VY, Korkushko OV. inventor; Institute of Gerontology NAMS of Ukraine, assignee. The method of determining the functional state of the endothelium of microvessels in the elderly. UA patent 46415. 2002 Oct 30]. [Ukrainian].

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.