Cerebrolysin administration counteracts elevated oxidative stress in blood of patients with Parkinson’s disease
O.O. Gonchar1, I.M. Karaban2, N.V. Karasevich2, L.V. Bratus1, I.M. Mankovska1
- Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
- Chebotarev Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kyiv,
DOI: https://doi.org/10.15407/fz68.04.020

Abstract
Effects of cerebrolysin (CBL) on prooxidant-antioxidant balance and oxidative stress (OS) developing in
blood of patients with Parkinson’s disease (PD) were studied. Twenty patients with PD and 10 healthy
persons (control) participated in this study. Clinical diagnosis of PD was established according UK Brain
Bank Criteria; the grades of PD were II-III after Hoehn/Yahr. PD patients received therapy with CBL
administration intravenously at dose 20 ml (61.5 mg/kg) per day along 10 days. As OS biomarkers, lipid
peroxidation (from the formation of thiobarbituric acid – reactive substances, TBARS), H2O2 production,
the activities of SOD, catalase, and GPx, as well as glutathione pool indexes were measured in blood
plasma and erythrocytes. It was established a significant rise in TBARS in plasma and H2O2 contents in
erythrocytes from patients with PD compared to control. These events were accompanied by an increase in
the SOD and catalase activities in plasma and a decrease in GSH content and GPx activity in erythrocytes.
CBL administration counteracts the TBARS accumulation, reduces hyperactivation of SOD and catalase in
plasma compared with the CBL-untreated patients. In erythrocytes of PD patients, CBL injection caused
the limitation of H2O2 production as well as promotion the GSH pool recovery through an increase in GSH
level and GPx activity.
Keywords:
oxidative stress; cerebrolysin; Parkinson’s disease
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