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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2022; 68(4): 11-19

RESIDUAL EFFECT OF WATER-SOLUBLE C60 FULLERENE ON THE MUSCLE SOLEUS AND MUSCLE GASTROCNEMIUS CONTRACTION IN RATS WITH THE DEVELOPMENT OF FATIGUE

D.M. Nozdrenko1, O.O. Gonchar2, K.I. Bogutska1, M.M. Okhramovych1, I.V. Pampuha1, N.E. Nurishchenko1, Yu.I. Prylutskyy1

  1. Taras Shevchenko National University of Kyiv, Ukraine
  2. O.O. Bogomoletz Institute of Physioligy, National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz68.04.011


Abstract

A comparison of biomechanical and biochemical markers of muscle soleus and muscle gastrocnemius fatigue in rats for two days after 5 days of using antioxidant C60 fullerene (daily dose was 1 mg·kg-1) was performed. It was shown that its long-term use to increase muscle strength response against the background of muscle fatigue by 60-65 and 35-40% in slow and fast muscle, respectively. The residual effect of water-soluble C60 fullerene on slow muscle remains significant (20-25%) even after 2 days after discontinuation of the drug. At the same time, its residual effect on fast muscle on the 2nd day remains at a minimum level, which does not significantly increase muscle performance. Prolonged usage of water-soluble C60 fullerene helps to reduce oxidative processes by 30-40% in fast and by 21-25% in slow muscles by maintaining a balance between prooxidants and antioxidant defense system. A comparative analysis of oxidative stress markers and indicators of the state of antioxidant defense systems in fast and slow muscles showed that the residual therapeutic effect of water-soluble C60 fullerene after long-term use is 30-40% higher in muscle soleus than in muscle gastrocnemius. The obtained results demonstrate the long-term kinetics of water-soluble C60 fullerene excretion from the body, which contributes to long-term (at least two days) compensatory activation of the endogenous antioxidant system in response to muscle stimulation, which should be considered when developing new therapeutic drugs based on it.

Keywords: muscle soleus; muscle gastrocnemius; muscle fatigue; C60 fullerene; biomechanical parameters of muscle contraction; biochemical indicators of muscle tissue.

Full text: (PDF, in Ukrainian)

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