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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2022; 68(4): 3-10


L.A. Bodretska, I.S. Shapovalenko, I.A. Antonyuk-Shcheglova, O.V. Bondarenko, S.S. Naskalova, V.B. Shatilo

    D.F. Chebotarev Institute of Gerontology NAMS of Ukraine, Kyiv, Ukraine


Age-related changes in the stiffness characteristics of the left ventricular (LV) myocardium and the possibility of using them to determine a person’s biological age (BA) were investigated. 188 practically healthy people (115 women and 73 men) were examined, divided by age into 5 groups: I - 30-39 years old (n = 25), II - 40-49 years old (n = 40), III - 50-59 years old (n = 38), IV - 60-69 years old (n = 46), V - 70-79 years old (n = 39). All were examined clinically, echocardiography was performed, the biological age of the cardiovascular system (CVS) was calculated according to the Framingham scale. In practically healthy people, with age, the indicators of left ventricular myocardial stiffness and the energy cost of the heart work statistically significantly increase, and residual energy decreases. Excess BA of the examined in relation to their calendar age was detected in 4 (10%, 95% CI 2.6-21.5), 12 (31.6%, 95% CI 17.6-47.6) and 14 (30.4%, 95% CI 17.8- 44.8) persons in age groups 40-49, 50-59 and 60-69 years, respectively, which indicates accelerated aging of the CVS. A direct correlation of moderate strength between biological age and indicators of the energy cost of the work of the heart has been established. It is advisable to use indicators of myocardial stiffness and energy spent on heart contraction as markers of aging to determine BA CVS.

Keywords: biological age of the cardiovascular system; myocardial stiffness; energy cost of the heart.


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