STUDY OF THE IMMUNE DISORDERS IN NONSPECIFIC CHRONIC INFLAMMATORY DISEASES OF THE GENITAL ORGANS
К.І. Davydenko, D.V. Maltsev, Yu.A. Batman, L.V. Natrus
O.O. Bogomolets National Medical University, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz68.03.068
Abstract
To study immune disorders: immunograms of 50 adult women
and 41 girls with recurrent non-specific genital inflammations,
were performed in order to characterize the immunodeficiency
in general and justify the treatment correction. The following gynecological examination procedures were performed:
bacterioscopic, bacteriological, cytological and PCR tests,
which didn’t reveal the specific infections. The control group
was represented by 14 women and 14 girls of the same age,
without appropriate complaints, healthy on gynecological
examination. The patients with recurrent non-specific genital
inflammations with the NKT-lymphocytes cytotoxic cells
deficiency made up 65%, those with the immunoglobulin E
(IgE) deficiency – 56%, the group with combined deficiency
of both IgE and Natural Killer T-cell (NKT) – 33%. The IgE
molecule content in morbid girls was almost twice less than
that of the healthy ones, in adult women the IgE deficiency
was 2.5 times less. The decrease in the NKT-lymphocytes in
the group of girls was 4.9 times less compared to the control,
and in healthy women, the decrease made up 1.9 times. The
detected increase of small circulating complexes in blood
plasma, which was observed in 88% of the patients, may be
explained by the manifestations of the immune response to
chronic infection in the genitals. The general immunoassay of
patients with the non-specific genital inflammations showed
the following immune disorder structure: the adaptive immunity humoral component disorder was in almost 70% of
cases, the inborn immunity cellular component was in almost
60% of cases, the adaptive immunity cellular component was
in 28% of cases, complement system disorders were in 26% of
cases, and phagocytosis disorders were in 14% of cases. These
immune disorders may be regarded as the basis of pharmacological correction aimed at covering for the immunodeficiency
and intensification of the affected mucosa immune resistance.
Keywords:
immunodeficiency; IgE; cytotoxic cells; NKTlymphocytes; recurrent inflammation.
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