SPONTANEOUS POST-TRAUMATIC RECOVERY OF MOTOR FUNCTION OF THE HINDLIMB IN MALE MICE
Yu.A. Nesterenko1, O.A. Rybachuk1,2
- Bogomoletz Institute of Physiology of the National Academy of Science of Ukraine;
- State Institute of Genetic and Regenerative Medicine, Kyiv, Ukraine;
DOI: https://doi.org/10.15407/fz68.03.015
Abstract
We studied the level of spontaneous post-traumatic recovery
of motor function in male FVB mice. The left-side spinal cord
hemisection was a model of damage. The locomotor activity
and spasticity of the hindlimb were determined using the BBB
and B scales and the Ashword scale during the first 12 weeks
of the post-traumatic period. According to the results of the
experimental study, at a later date in the post-traumatic period,
the restoration of the function of the hind limb was observed
at the level of 3.22 ± 0.46 points (out of 21 possible) on the
BBB scale and 1.88 ± 0.27 points (out of 9 possible) on the B
scale. Such indicators of hind limb locomotor activity conform
to the phase of early recovery. However, at all studied time
intervals after spinal cord injury, a consistently high level of
hindlimb spasticity in experimental animals was noted – 3.17
± 0.46 (out of 4 possible) on the Ashword scale.
Keywords:
spinal cord injury; modeling; left-side spinal cord hemisection; FVB mice; BBB scale; B scale; spasticity.
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