BENFOTHIAMINE AS AN ANTIOXIDANT IN THE DRAINAGE ZONE OF THE EYE IN COMBINED MODELING GLACOMA AND DIABETES
I.N. Mikheytseva1, V.R. Yurevich2
- Filatov Institute of Eye Diseases and Tissue Therapy of NAMS of Ukraine, Odesa, Ukraine
- Danylo Halytsky Lviv National Medical Unibersity, Ukraine
DOI: https://doi.org/10.15407/fz68.02.068
Abstract
During experimental glaucoma with diabetes in rabbits, in
the filtering tissues of the eye, a state of oxidative stress is
formed manifested by a significant decrease in the activity
of antioxidant enzymes and the accumulation of products of
free radical oxidation of lipids and proteins. Administration
of a lipid-soluble form of vitamin B1 benfotiamine effectively
reduced the manifestations of oxidative stress in the tissues
of the anterior chamber of the animal eyes. This biologically
active substance increased antioxidant capacity in tissues
by activating antiradical protection enzymes: superoxide
dismutase activity increased by 51%, catalase by 36% and
glutathione peroxidase by 45% compared to the untreated animals. In addition, the processes of lipid peroxidation and
oxidative destruction of protein molecules were decreased
under the influence of benfotiamine. The level of malondialdehyde (MDA) was reduced by 47%, and the marker of
oxidative damage to proteins of CO-groups by 35% relative
to the untreated group. The results obtained may be a basis for
further studies of the pharmacological substance benfotiamine
in the clinic of glaucoma accompanied by diabetes, which will
expand the arsenal of pathogenetically sound therapy of this
serious disease.
Keywords:
benfotiamine; oxidative stress; glaucoma; diabetes; eye tissue.
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