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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2022; 68(2): 23-28


A.A. Кotvytska1, K.V. Tykhonovych1, Т.D. Кryvoruchko1, S.M. Berehovyi2, К.S. Neporada1

  1. Poltava State Medical University, Ukraine
  2. Taras Shevchenko National University of Kyiv, ECS “Institute of Biology and Medicine”, Ukraine


The aim of our research is to study the condition of periodontal tissues of rats against the background of prolonged alcoholism. The studies were performed on 19 white nonlinear rats weighing 180-220 g, which were randomly divided into 2 groups. Rats of the first group served as controls. They were injected intragastrally with saline for 72 days. The rats of the second group for 72 days were intragastrically injected with increasing concentrations of ethanol according to the following scheme: 1-24 days - 11.8%; 25-48 - 23.6%; 49- 72 days - 37%. In rat soft periodontal tissues, free fucose content as a monomer of fucoproteins, glycosaminoglycans as proteoglycan heteropolysaccharides, total proteolytic activity, total antitryptic activity, TBA-active products, oxidatively modified proteins and catalase activity was determined. 72- day alcoholization of rats caused an increase in periodontal tissue content of TBA-active products by 74.7%, the content of oxidatively modified proteins by 28.9% and catalase activity by 33.3%, indicating the activation of free radical processes. At the same time, the total proteolytic activity in periodontal tissues decreased by 20.6% against the background of a decrease in the activity of proteinase inhibitors by 9.6%. Also, under conditions of long-term administration of ethyl alcohol to animals an increased depolymerization of fucoproteins and proteoglycans of periodontal connective tissue was observed, as evidenced by an increase in free fucose content by 37.5% and glycosaminoglycans 175.4%. Under conditions of longterm administration of ethyl alcohol to rats, an increased depolymerization of fucoproteins and proteoglycans of periodontal connective tissue is observed, which plays a leading role in the fixation and stability of teeth.

Keywords: alcohol; periodontal tissues; oxidative stress; proteases; protease inhibitors.


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