Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2022; 68(2): 9-13

Adult resocialization restores sociability, reduced by adolescent social isolation in rats

O.М. Nikolaienko1, E.V. Isaeva2

  1. O.O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
  2. Medical College of Wisconsin, Milwaukee, USA
DOI: https://doi.org/10.15407/fz68.02.009


Abstract

We aimed to assess the effect of 6-week adolescent social isolation on sociability and social novelty preference in male Wistar rats. In addition, we examined whether isolation effects would persist after adult resocialization. Our findings demonstrate that social isolation resulted in decreased social interest (the time spent interacting with an unfamiliar rat of the same sex and age decreased from 115.4 ± 13.3 s in group-housed animals to 82.3 ± 11.0 s in isolated, P < 0.05), while social novelty preference was not significantly different between isolated and group-housed rats. We also report that 6-week resocialization was sufficient to restore social interaction levels in isolated rats (time spent with an unfamiliar rat was 117.9 ± 12.6 s in isolated animals and 102.5 ± 10.9 s in group-housed). These findings may be useful for better understanding the impact of social deprivation on human subjects, which has recently become especially relevant due to the restrictions of the COVID-19 pandemic.

Keywords: social isolation; adolescence; resocialization; sociability; social novelty.

Full text: (PDF, in English)

References

  1. Blakemore SJ. The social brain in adolescence. Nat Rev Neurosci. 2008;9(4):267-77. CrossRef PubMed
  2. Keshavan M, Giedd JN. Why do many psychiatric disorders emerge during adolescence? Nat Rev Neurosci. 2008;9(12):947-57. CrossRef PubMed PubMedCentral
  3. Burke AR, McCormick CM, Pellis SM, Lukkes JL. Impact of adolescent social experiences on behavior and neural circuits implicated in mental illnesses. Neurosci Biobehav Rev. 2017;76:280-300. CrossRef PubMed
  4. McCormick CM, Green MR, Simone JJ. Translational relevance of rodent models of hypothalamic-pituitary- adrenal function and stressors in adolescence. Neurobiol Stress. 2017;6:31-43. CrossRef PubMed PubMedCentral
  5. Romeo RD, Bellani R, Karatsoreos IN, Chhua N, Vernov M, Conrad CD, McEwen BS. Stress history and pubertal development interact to shape hypothalamic-pituitary-adrenal axis plasticity. Endocrinology. 2006;147(4):1664-74. CrossRef PubMed
  6. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiat. 2005;62(6):593-602. CrossRef PubMed
  7. Orben A, Tomova L, Blakemore SJ. The e ects of social deprivation on adolescent development and mental health. Lancet Child Adolesc Heal. 2020;4(8):634-40. CrossRef
  8. Lu L, Bao G, Chen H, Xia P, Fan X, Zhang J, Gang P, Lan M. Modi cation of hippocampal neurogenesis and neuroplasticity by social environments. Exp Neurol. 2003;183(2):600-9. CrossRef
  9. Brenes JC, Fornaguera J. The e ect of chronic 쫀uoxetine on social isolation-induced changes on sucrose consumption, immobility behavior, and on serotonin and dopamine function in hippocampus and ventral striatum. Behav Brain Res. 2009;198(1):199-205. CrossRef PubMed
  10. Shao Y, Yan G, Xuan Y, Peng H, Huang QJ, Wu R, Xu H. Chronic social isolation decreases glutamate and glutamine levels and induces oxidative stress in the rat hippocampus. Behav Brain Res. 2015;282:201-8. CrossRef PubMed
  11. Da Silva NL, Ferreira VMM, De Padua Carobrez A, Morato GS. Individual housing from rearing modi es the performance of young rats on the elevated plus-maze apparatus. Physiol Behav. 1996;60(6):1391-6. CrossRef
  12. Chang CH, Gean PW. The ventral hippocampus controls stress-provoked impulsive aggression through the ventromedial hypothalamus in post-weaning social isolation mice. Cell Rep. 2019;28(5):1195-205. CrossRef PubMed
  13. Lukkes J, Vuong S, Scholl J, Oliver H, Forster G. Corticotropin-releasing factor receptor antagonism within the dorsal raphe nucleus reduces social anxiety-like behavior following early-life social isolation. J Neurosci. 2010;29(32):9955-60. CrossRef PubMed PubMedCentral
  14. Van Den Berg CL, Hol T, Van Ree JM, Spruijt BM, Everts H, Koolhaas JM. Play is indispensable for an adequate development of coping with social challenges in the rat. Dev Psychobiol. 1999;34(2):129-38. CrossRef
  15. Park G, Ryu C, Kim S, Jeong SJ, Koo JW, Lee YS, Kim SJ. Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice. Cell Rep. 2021;35(6):109104. CrossRef PubMed
  16. Makinodan M, Rosen KM, Ito S, Corfas G. A criti- cal period for social experience-dependent oligo- dendro cyte maturation and myelination. Science. 2012;337(6100):1357-60. CrossRef PubMed PubMedCentral
  17. Meng Q, Li N, Han X, Shao F, Wang W. Peri-adolescence isolation rearing alters social behavior and nociception in rats. Neurosci Lett. 2010;480(1):25-9. CrossRef PubMed
  18. Moy SS, Nadler JJ, Perez A, Barbaro RP, Johns JM, Magnuson TR, Piven J, Crawley JN. Sociability and preference for social novelty in ve inbred strains : an approach to assess autistic-like behavior in mice. Genes Brain Behav. 2004;3:287-302. CrossRef PubMed
  19. Netser S, Meyer A, Magalnik H, Zylbertal A, de la Zerda SH, Briller M, Bizer A, Grinevich V, Wagner S. Distinct dynamics of social motivation drive differential social behavior in laboratory rat and mouse strains. Nat Commun. 2020;11:5908. CrossRef PubMed PubMedCentral
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.