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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2022; 68(2): 3-8


Partial deactivation of default-mode brain network during simple motor task execution

O.M. Omelchenko, M.Y. Makarchuk , M.P. Bondarenko, O.V. Bondarenko

    Taras Shevchenko National University of Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz68.02.003

Abstract

We used model based functional MRI independent component analysis approach for the detection and characterization of the described networks functioning during simple motor task execution. Direct connection between the task execution and anticorrelated functional connectivity of sensory-motor and default mode networks was shown. We observed blood oxygenation level dependent signal (BOLD) frequency characteristics of the default mode network (DMN) together with the sensory motor network (SMN). The results demonstrate a reproducible specific configuration of BOLD low-frequency spectrum. Neural network BOLD spectral pro㌳le approach may be used for future analysis of its functioning and dynamics rules of brain regions connectivity. Regions of precuneus and posterior cingulate cortex were shown to deactivate just partially. Sensorimotor and default-mode networks were functionally connected in the anticorrelated manner with the prevailing frequencies of the BOLD signal oscillation f1 = 0.0153 ± 0.0051 Hz and f2 = 0.0204 ± 0.0051 Hz, where f – frequency of BOLD oscillation. At our study we have found out, that only some separate parts of pC and PCC were deactivated during the task execution. This possibly might support the hypothesis that non deactivated regions of precuneus (pC) and posterior cingulate cortex (PCC) remain active to regulate the transitions from the activated state to the deactivated and back while monitoring the external environment and commands. The last may support the hypothesis of the role of posterior cingulate cortex as a “hub” in default mode networks where non deactivated parts remain active for further control of others default mode networks region state switching.

Keywords: default mode network; sensory-motor network; fMRI; independent component analysis.

References

  1. Ogawa S, Lee T, Kay A, Tank D. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci USA. 1990;87(24):9868-72. CrossRef PubMed PubMedCentral
  2. Logothetis NK, Pauls J, Augath M, Trinath T, Oeltermann A. Neurophysiological investigation of the basis of the fMRI signal. Nature. 2001;412(6843): 50-157. CrossRef PubMed
  3. Greicius MD, Krasnow B, Reiss AL, Menon V. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci USA. 2003;100 (1):253-8. CrossRef PubMed PubMedCentral
  4. Zuo X-N, Di Martino A, Kelly C, Shehzad ZE, Gee DG, Klein DF, Castellanos FX, Biswal BB, Milham MP. The oscillating brain: complex and reliable. NeuroImage. 2010;49(2):1432-45. CrossRef PubMed PubMedCentral
  5. Riehle A, Vaadia E. Motor cortex in voluntary movements: a distributed system for distributed functions. Boca Raton: CRC Press. 2005;426(13). CrossRef PubMedCentral
  6. Allison J, Meador K, Loring D, Figueroa R, Wright J. Functional MRI cerebral activation and deactivation during Knger movement. Neurology. 2000;54(3):135. CrossRef PubMed
  7. Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman G.L. A default mode of brain function. Proc Natl Acad Sci USA. 2001;98(2):676-82. CrossRef PubMed PubMedCentral
  8. Laird AR, EickhoE SB, Li K, Robin DA, Glahn DC, Fox PT. Investigating the functional heterogeneity of the default mode network using coordinate-based meta- analytic modeling. J Neurosci. 2009;29(46):14496-505. CrossRef PubMed PubMedCentral
  9. Worsley KJ, Liao CH, Aston J, Petre V, Duncan GH, Morales F, Evans AC. A general statistical analysis for fMRI data. NeuroImage. 2002;15(1):1-15. CrossRef PubMed
  10. Beckmann CF, Smith SM. Probabilistic independent component analysis for functional magnetic resonance imaging. Med Imag, IEEE Transact. 2004;23(2):137-52. CrossRef PubMed
  11. Rijntjes M, Dettmers C, B'chel C, Kiebel S, Frackowiak RS, Weiller C. A blueprint for movement: functional and anatomical representations in the human motor system. J Neurosci. 1999;19(18):8043-8. CrossRef PubMed PubMedCentral
  12. Gao W, Gilmore JH, Alcauter S, Lin W. The dynamic reorganization of the default-mode network during a visual classification task. Front Syst Neurosci. 2013;7. CrossRef PubMed PubMedCentral

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