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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2022; 68(1): 69-73


N.M. Veselovska1,2, O.G. Pyatiizbyantseva2, I.B. Zaporozhchenko1,2, Z.F. Veselovska1,2

  1. Kyiv Medical University, Ukraine
  2. Ophthalmology Clinic of Kyiv City Hospital No. 1, Kyiv, Ukraine


To conduct an analysis of the anterior surface of the eye in patients with the newly diagnosed primary open-angle glaucoma in order to choose treatment with or without preservative. We evaluated the front surface of the eye in 46 patients (92 eyes) diagnosed with primary open-angle glaucoma: 20 men and 26 women aged from 58 to 80 years. The anterior surface of the eye was examined using an analyzer of the anterior eye. The signs of previously diagnosed dry eye syndrome (DES) with various manifestations of dysfunction of meibomian glands and complaints about dry eyes, foreign body sensation, lacrymation and blurred vision were reported in 39 patients (85%). Based on the examination results, preservative-free topical hypotensive medications were recommended for these 39 patients. In order to preserve visual functions and quality of life in patients with newly diagnosed POAG, it is advisable to conduct a preliminary assessment of the condition of the anterior surface of the eye when prescribing drug therapy in order to rationalize the choice of first-line drugs with or without preservative in accordance with the European recommendations of Diagnosis and Treatment for glaucoma.

Keywords: preservative-free medications; dry eye syndrome; primary open-angle glaucoma.


  1. Stapleton F, Alves M, Bunya VY, Jalbert I, Lekhanont K, Malet F, et al. TFOS DEWS II epidemiology report. Ocul Surf. 2017;15(3):334-65. CrossRef PubMed
  2. Şimşek C, Doğru M, Kojima T, Tsubota K. Current Management and Treatment of Dry Eye Disease. Turk J Ophthalmol. 2018;48(6):309-13. CrossRef PubMed PubMedCentral
  3. Brzheskiy VV, Egorova GB, Egorov EA. Dry eye syndrome and ocular surface disease: clinic, diagnostics, treatment. Moscow; 2016. [Russian].
  4. Brzheskii VV, Somov EE. Dry eye syndrome. Saint Petersburg;1998. [Russian].
  5. Golubev SYu, Kuroyedov AV. Choice of cost-effective medicine for the prevention and treatment of dry eye syndrome. Sindrom sukhogo glaza: Spets. izdanie Moskovskoy assotsiatsii oftalmologov. 2002:3:12-4. [Russian].
  6. Cvenkel B, Štunf Š, Srebotnik Kirbiš I, Strojan Fležar M. Symptoms and signs of ocular surface disease related to topical medication in patients with glaucoma. Clin Ophthalmol. 2015;9:625-31. CrossRef PubMed PubMedCentral
  7. Brzhevskiy VV, Somov EE. Dry eye syndrome in patients with inherited glaucoma. Russ J Clin Ophthalmol. 2003;4(3):139-41. [Russian].
  8. Boyko EV, Simakova IL, Yakushev DY, Ignat'ev SA, Alekseev IB, Mel'nikova NV, et al. Russ Ann Ophthalmol. 2015;131(3):22-6. [Russian]. CrossRef PubMed
  9. Realini T, Barber L, Burton D. Frequency of asymmetric intraocular pressure fluctuations among patients with and without glaucoma. Ophthalmology. 2002;109(7):1367-71. CrossRef
  10. Varma R, Hwang LJ, Grunden JW, Bean GW. Inter-visit intraocular pressure range: an alternative parameter for assessing intraocular pressure control in clinical trials. Am J Ophthalmol. 2008;145(2):336-42. CrossRef PubMed
  11. Kuroedov AV. Primary open-angle glaucoma in different age groups. Glaucoma News. 2007;4:31. [Russian].
  12. Kurysheva NI, Parshunina OA, Ardzhevnishvili TD, Arakelyan RK, Lagutin MB. New diagnostic markers of glaucoma. Glaucoma News. 2015;1(33):131-3. [Russian].
  13. Baudouin C. Detrimental effect of preservatives in eyedrops: Implications for the treatment of glaucoma. Acta Ophthalmol. 2008;86(7):716-26. CrossRef PubMed
  14. Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90(3):262-7. CrossRef PubMed PubMedCentral
  15. Lemij HG, Hoevenaars JG, van der Windt C, Baudouin C. Patient satisfaction with glaucoma therapy: reality or myth? Clin Ophthalmol. 2015;9:785-93. CrossRef PubMed PubMedCentral
  16. Arici MK, Arici DS, Topalkara A, Güler C. Adverse effects of topical antiglaucoma drugs on the ocular surface. Clin Exp Ophthalmol. 2000;28(2):113-7. CrossRef PubMed
  17. Abysheva LD, Avdeev RV, Alexandrov AS, Arapiev MU, Bakunina NA, Baranova NA, et al. Influence of local hypotensive glaucoma therapy on the development and progression of dry eye syndrome. Russ J Clin Ophthalmol. 2017;17(2):74-82. [Russian].
  18. Veselovskaya ZF, Veselovskaya NN. Zaporozhchenko IB. Preservative free tafluprost in the medical treatment of POAG in patients with type 2 diabetes mellitus. Egypt J Ophthalmol. ID: EJOMOS-2102-10-15
  19. Erb C, Gast U, Schremmer D. German register for glaucoma patients with dry eye. I. Basic outcome with respect to dry eye. Graefes Arch Clin Exp Ophthalmol. 2008;246(11):1593-601. CrossRef PubMed
  20. Terminology and Guidelines for Glaucoma. 5th ed. Savona: PubliComm; 2020.

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