EFFECT OF INTRANASAL ADMINISTRATION OF DEGYDROEPIANDROSTERONE ON EMOTIONAL STATUS AND ZOOSOCIAL BEHAVIOR OF RATS UNDER CONDITIONS OF PROLONG ALCOHOLIZATION
V.V. Geiko1, M.S. Geiko2, T.V. Selyukova3
- SI «Institute of Neurology, Psychiatry and Narcology of National Academy of Medical Sciences of Ukraine», Kharkiv, Ukraine
- Regional Clinical Narcological Hospital, Kharkiv, Ukraine
- National University of Civil Protection of Ukraine, Kharkiv, Ukraine
We have investigated the effect of the intranasal degydroepiandrosterone (DHEA) treatment on the emotional status and
zoosocial behavior of rats during ethanol withdrawal compared
to the level of voluntary ethanol consumption and its preference at the 2-bottle test. It was shown that under conditions of
renewal of alcohol access, the highest decrease in the intensity
of its usage (by 75%), as compared to controls, was found in
all experimental animals. Additionally, DHEA has promoted
significant reduction (by 72%) in the pathological addiction to
ethanol. These results, combined with the restoration of zoosocial relationships with the predominance of the socio-centric
type, have reflected the normalizing effect of neurosteroids
on the emotional behavior of the alcoholized animals, which
suggest certain therapeutic potential of DHEA directed to a
decrease in the level of ethanol addiction.
dehydroepiandrosterone; intranasal administration; emotional and motor activity; anxiety-phobic status; voluntary use of ethanol; ethanol preference index; zoosocial behavior.
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