Role of hydrogen sulfide in the regulation of respiration, blood flow and bile secretory function of the liver
P.I. Yanchuk, I.V. Komarov, Y.А. Levadianska, L.O. Slobodianyk, S.P. Veselsky, T.V. Vovkun, L.Ya. Shtanova, E.M. Reshetnik
Taras Shevchenko National University of Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz67.05.011
Abstract
In acute experiments on laboratory rats, intra-portal administration of L-cysteine (20 mg/kg), the precursor of hydrogen sulfide synthesis, stimulated oxygen consumption of liver by 38.6% and reduced oxygen tension
by 37.1%. Activation of tissue respiration occurred due to the strengthening of oxygen-dependent synthetic
processes in liver, in particular those associated with mitochondrial enzyme-catalysed bile acid biosynthesis
through the acidic pathway. The concentrations of taurocholic acid and mixtures of taurodeoxycholic and
taurohenodeoxycholic acids increased by 10.3 and 17.9%, respectively, compared to the initial levels. In
addition, the level of free cholesterol was decreased by 33.9% and esterification processes were intensified,
as indicated by an increase in the concentration of esterified cholesterol by 22.6% in the bile of rats. The
latter was to some extent confirmed by a decrease in the level of free bile acids (by 15.8%) involved in the
biosynthesis of cholesterol esters and intensification of tissue respiration in the liver. L-cysteine dilated
intrahepatic vessels, resulting in a significant decrease of the systemic blood pressure and blood pressure in
the portal vein by 17.6 and 24.5%, respectively. L-cysteine increased the rate of local blood flow in the liver
and blood supply by 28.2 and 24.4%, respectively. Blockade of cystathionine-γ-lyase by DL-propargylglycine
(11 mg/kg) significantly inhibited the L-cysteine-induced tissue respiration and bile acid biosynthesis in the
liver. Administration of DL-propargylglycine resulted in constriction of blood vessels of the liver and, as a
consequence, to an increased blood pressure and a decreased blood flow rate in tissue. Our data point to
an involvement of hydrogen sulfide in the regulation of liver tissue respiration and bile secretory function.
Keywords:
hydrogen sulfide; L-cysteine; liver; oxygen tension and consumption; bile secretion; bile acids; cholesterol; lipids; tissue blood flow; blood supply; portal pressure
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