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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2021; 67(4): 76-85


RETROSPECTIVE ANALYSIS OF CORONAVIRUS DISEASE LETHAL CASES

E.O. Kindrativ1, V.M. Vasylyk2, V.M. Matskevych2, V.M. Kostyuk1, V.A. Semchenko1, V.O. Voronych1

    1Ivano-Frankivsk National Medical University; 2PNPE (Public Non-Profit Enterprise) «Regional Clinical Hospital of Ivano-Frankivsk Regional Council»;
DOI: https://doi.org/10.15407/fz67.04.076

Abstract

There was performed a statistical analysis of 164 records of pathological examination of persons who died of coronavirus disease during April-November, 2020. It is determined that the share of males was 62.20%, and females – 37.80%; the average age of the deceased persons was 64.40 ± 13.79 years. The largest number of lethal cases (57.32%) falls on the age category of 60-79 years, and the smallest (6.71%) – on the age category of 20-39 years. It is important that men predominate in all age groups. The most common direct causes of death were: respiratory failure – 78.05%, multiorgan failure – 17.07%. At the same time, respiratory insufficiency was dominant in all age categories, while the share of multiorgan failure was the largest in the group of persons aged 20-39 years. As a result of the analysis of thromboembolic complications found in 10.37% of cases, there were 3.05% of cases of acute coronary syndrome and acute cerebrovascular disorder, 1.83% of cases – acute thrombosis of the arteries of the lower extremities, 1.22% of cases – acute thrombosis of the mesenteric vessels, and 0.61% – disseminated intravascular coagulation of blood and acute pulmonary thromboembolism. Morphological examination of the lung tissue of the deceased persons revealed signs of diffuse alveolar damage involving the microcirculatory bed vessels in the pathological process. According to the results of bacteriological examination of the lungs there were revealed some signs of bacterial infection in 51.83% of cases, and signs of fungal infection – in 15.85% of cases. The most common (23.78%) was the growth of Klebsiella pneumoniae. The most common comorbidities were: coronary heart disease – 62.20%, hypertension – 29.27%, non-insulin dependent diabetes mellitus – 11.59%, obesity – 10.37%, anemia – 6.71% and chronic obstructive pulmonary disease – 2.44%. In 10.98% of cases diabetes was the main underlying disease. The data obtained may indicate an adverse effect of these diseases on the course of coronavirus disease.

Keywords: coronavirus disease; COVID-19; mortality; retrospective analysis; pathophysiology; morphology

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