RETROSPECTIVE ANALYSIS OF CORONAVIRUS DISEASE LETHAL CASES
E.O. Kindrativ1, V.M. Vasylyk2, V.M. Matskevych2, V.M. Kostyuk1, V.A. Semchenko1, V.O. Voronych1
1Ivano-Frankivsk National Medical University;
2PNPE (Public Non-Profit Enterprise) «Regional Clinical
Hospital of Ivano-Frankivsk Regional Council»;
DOI: https://doi.org/10.15407/fz67.04.076
Abstract
There was performed a statistical analysis of 164 records of
pathological examination of persons who died of coronavirus
disease during April-November, 2020. It is determined that
the share of males was 62.20%, and females – 37.80%; the
average age of the deceased persons was 64.40 ± 13.79 years.
The largest number of lethal cases (57.32%) falls on the age
category of 60-79 years, and the smallest (6.71%) – on the age
category of 20-39 years. It is important that men predominate in
all age groups. The most common direct causes of death were:
respiratory failure – 78.05%, multiorgan failure – 17.07%. At
the same time, respiratory insufficiency was dominant in all
age categories, while the share of multiorgan failure was the
largest in the group of persons aged 20-39 years. As a result of
the analysis of thromboembolic complications found in 10.37%
of cases, there were 3.05% of cases of acute coronary syndrome
and acute cerebrovascular disorder, 1.83% of cases – acute
thrombosis of the arteries of the lower extremities, 1.22% of
cases – acute thrombosis of the mesenteric vessels, and 0.61%
– disseminated intravascular coagulation of blood and acute
pulmonary thromboembolism. Morphological examination
of the lung tissue of the deceased persons revealed signs of
diffuse alveolar damage involving the microcirculatory bed
vessels in the pathological process. According to the results of
bacteriological examination of the lungs there were revealed
some signs of bacterial infection in 51.83% of cases, and signs
of fungal infection – in 15.85% of cases. The most common
(23.78%) was the growth of Klebsiella pneumoniae. The most
common comorbidities were: coronary heart disease – 62.20%,
hypertension – 29.27%, non-insulin dependent diabetes
mellitus – 11.59%, obesity – 10.37%, anemia – 6.71% and
chronic obstructive pulmonary disease – 2.44%. In 10.98%
of cases diabetes was the main underlying disease. The data
obtained may indicate an adverse effect of these diseases on
the course of coronavirus disease.
Keywords:
coronavirus disease; COVID-19; mortality; retrospective analysis; pathophysiology; morphology
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