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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2021; 67(3): 87-99

THE ROLE OF ENDOTHELIUM IN THE REGULATION OF THE AGGREGATE STATE OF BLOOD UNDER NORMAL CONDITIONS, IN ATHEROSCLEROSIS AND ARTERIAL HYPERTENSION

R.Yu. Marunych1, O.V. Gornytska1, A.V. Gudzenko2, O.A. Salnyk3, A.O. Hrabovskyi1, G.K. Bereznytskyj1, Ye.M. Makogonenko1

  1. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
  2. PHEE “Kyiv Medical University”, Ukraine
  3. Taras Shevchenko National University of Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz67.03.087


Abstract

The structure and functions of the endothelium under normal conditions and a number of pathologies are reviewed in this work with the focus on its role in maintaining the balance between pro- and anticoagulant function of blood in different vascular beds. The role of endothelium in the synthesis and secretion of NO and other vascular regulators is highlighted. The mechanisms of its dysfunction, the role and interconnection of pathological changes in diseases such as atherosclerosis and hypertension are described.

Keywords: endothelium; hemostasis; dysfunction; pro- and anticoagulant function.

Full text: (PDF, in Ukrainian)

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