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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2021; 67(3): 54-74

The developmental neuroendocrinology of reproduction and adaptation: lessons from animal research

A.G. Reznikov

  1. V.P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, 04114 Kyiv, Ukraine


In order to commemorate the 30th anniversary of the establishing Department of Endocrinology of Reproduction and Adaptation at the V.P. Komisarenko Institute of Endocrinology and Metabolism (Kyiv, Ukraine), the results of animal research in the field of developmental neuroendocrinology of reproduction and adaptation in early ontogenesis are reviewed in the article. Special attitude is paid to sex differentiation of the brain and developmental programming of hypothalamic-pituitary-adrenal axis. Presented are reprogramming effects of perinatal steroids, stress, some drugs, and chemical endocrine disruptors on the developing brain. Phenomenology and neurochemical mechanisms underlying hormone-neurotransmitter imprinting of morphology of the hypothalamus, sexual behavior, reproductive and endocrine functions, and stress reactivity are under discussion. The results of the studies could contribute to prenatal prevention of neuroendocrine and behavioral disorders.

Keywords: brain; sexual differentiation; androgens; estrogens; glucocorticoids; neurotransmitters; prenatal stress; sexual behavior; stress reactivity; endocrine disruptors; rat.


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