THE CORRELATION BETWEEN IRON METABOLISM INDEXES AND THYROID HOMEOSTASIS IN CHILDREN WITH SIDEROPENIA AND IODINE DEFICIENCY
U.P. Shalamai, О.V. Zayats, N.M. Voronych-Semchenko
Ivano-Frankivsk National Medical University, Ukraine
Relationships between the iron metabolism indexes and
thyroid homeostasis in children were investigated. For that
purpose, 68 healthy children aged 6 to 11 years were examined
(35 boys and 33 girls) with adequate iron and iodine supply
(n =16), latent sideropenia (n = 16), mild iodine deficiency
(n = 18) and combination of latent iron deficiency and mild
iodine deficiency (n = 18). We found that in 13% of boys
with latent sideropenia, 78% of boys and as many girls with
mild iodine deficiency, 90% of boys and 88% of girls with
combined iodine and iron deficiency, the thyroid-stimulating
hormone (TSH) level in blood serum ranged from 2.5 to
4.2 mIU/l under the reference data of free triiodothyronine
(fT3) and thyroxine (fT4). This observation points for development of minimal thyroid insufficiency (MTI). According
to the TSH/fT4 index, MTI was found in 30% of boys and
38% of girls with combined iodine and iron deficiency. These
children form the group of risk for development of subclinical
hypothyroidism and require mandatory individual correction
of MTI by administration of potassium iodide. We found direct
moderate correlations between the contents of fT3 and fT4 in
serum and the hemoglobin level (Hb) in blood, between the
contents of the serum iron and ferritin (r from 0.42 to 0.64).
We found also an inverse moderate correlation between the
serum TSH content and indexes of iron metabolism (r from
–0.56 to –0.61), and a direct moderate correlation between
the TSH and total serum iron-binding capacity (r = 0.54).
Therefore, iron deficiency can be considered a risk factor
for the development of thyroid insufficiency, which requires
control of functional capacity of thyroid gland in case of iron
depot depletion. The most vulnerable period for the formation of thyroid dysfunction is a prepubertal age regardless
of gender. The advisability of determining the indicators of
iron metabolism and its correction under conditions of latent
sideropenia, mild iodine deficiency and their combination for
the prevention of MTI development was justified.
latent sideropenia; mild iodine deficiency; schoolage children.
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