|
|
|
|
EFFECT OF OBESITY ON BONE METABOLISM
I.G. Litovka
O.O. Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz67.02.067
Abstract
The review of current literature presents data on the prevalence
of obesity and its impact on bone metabolism. These results
suggest that there is a complex multilevel relationship between
the skeletal system, adipose tissue and energy metabolism.
However, informational analysis of the problem has shown
that there are still many unresolved issues regarding the
relationship between metabolic and osteopenic syndromes.
At the same time, studies of the state of the skeletal system
in metabolic syndrome and obesity can contribute to a deeper
understanding of the pathogenesis of osteopenic syndrome to
develop its treatment and prevention.
Keywords:
obesity; bone metabolic; source tissue
References
- World health organization global health observatory. Obesity: situation and trends, 2017. Available from http:// www.who.int/gho/ncd/risk_factors/obesity_text/en.
- European Association for the study of obesity. Facts & Statistics: Definitions of overweight and obese, 2017. Available from http://easo.org/task-forces/childhoodobesity-cotf/facts-statistics/.
- Shapses SA, Pop CL, Wang Y. Obesity is a concern for bone health with aging. Nutr Res. 2017;39:1-13.
CrossRef
PubMed PubMedCentral
- Misyura EV, Kazakov AV, Kravchun NA. Epidemiological aspects of obesity in Ukraine. Endocrinology. 2014;19 (4):3-25.[Russian].
- Ginzburg MM, Kozupitsa GS. Insulin resistance syndrome. Endocrsnol Probl. 1997;43(1):40-3. [Rusian].
CrossRef
- Grigoryan OR, Chernova TO, Antsiferov MB. Correction of insulin resistance in postmenopausal women. Reprod Probl. 2001;7 (4):53-61. [Russian].
- Danilov RK. Histology manual. Vol II. St. Petersburg: Spets Lit, 2011:513. [Russian].
- Savvidis C, Tournis S, Dede AD. Obesity and bone metabolism. Hormones. 2018;17:205-17.
CrossRef
PubMed
- Chooi Yu Chung, Ding C, Magkos F. The epidemiology of obesity. Metabolizm. 2019;92(1):6-10.
CrossRef
PubMed
- Natrus LV, Gayova LV, Byhovets MYu, Osadchuk YuS, Konovalov SE.The value of regulatory effects on lipid metabolism in during complicated diabetes mellitus. Fiziol. Zh. 2020;66(1):25-34. [Ukrainian].
CrossRef
- Watt J, Schlezinger JJ. Structurally-diverse, PPARγactivating environmental toxicants induce adipogenesis and suppress osteogenesis in bone marrow mesenchymal stromal cells. Toxicology. 2015;331:66-77.
CrossRef
PubMed PubMedCentral
- Pollock NK. Childhood obesity, bone development, and cardiometabolic risk factors. Mol Cell Endocrinol. 2015;410:52-63.
CrossRef
PubMed PubMedCentral
- Fleet JC, Schoch RD. Molecular mechanisms for regulation of intestinal calcium absorption by vitamin D and other factors. Crit Rev Clin Lab Sci. 2010;47:181-95.
CrossRef
PubMed PubMedCentral
- von Muhlen D, Safii S, Jassal SK, Svartberg J, BarrettConnor E.Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study. Osteoporos Int. 2007;18(10):1337-44.
CrossRef
PubMed
- de Paula FJA, Rosen CJ. Bone remodeling and energy metabolism: New perspectives. Bone Res. 2013; 1(1): 72-84.
CrossRef
PubMed PubMedCentral
- Wong SK, Chin K-Y, Suhaimi FH, Ahmad F, Ima-Nirwana S. The relationship between metabolic syndrome and osteoporosis: A review. Nutrients. 2016;8(6):347.
CrossRef
PubMed PubMedCentral
- Shapses SA, Sukumar D. Bone metabolism in obesity and weight loss. Annu Rev Nutr. 2012;32:287-309.
CrossRef
PubMed PubMedCentral
- Bolland MJ, Grey AB, Ames RW, Horne AM, Gamble GD, Reid IR. Fat mass is an important predictor of parathyroid hormone levels in postmenopausal women. Bone. 2006;38:317-21.
CrossRef
PubMed
- Pitroda AP, Harris SS, Dawson-Hughes B. The association of adiposity with parathyroid hormone in healthy older adults. Endocrine. 2009;36:218-23.
CrossRef
PubMed PubMedCentral
- Volkov VP. The morphofunctional state of the parathyroid glands during antipsychotic therapy, depending on age. Universum: medicine and pharmacology: electron. scientific journal, 2015;15(2). Available from https:// cyberleninka.ru ›article› morfofunktsionalnoe. [Rusian].
- Drincic AT, Armas LA, Van Diest EE, Heaney RP. Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity. Obesity (Silver Spring). 2012;20(7):1444-8.
CrossRef
PubMed
- Shapses SA, Pop C, Schneider SH. Vitamin D in Obesity and Weight Loss. In: Weaver CM, Daly RM, BischoffFerrari H, editors. Nutritional Aspects of Osteoporosis. Springer; London. 2016; 9-16.
CrossRef
- Mateos CG-F, Cayón-Blanco M. Weighthas a weak influence on calcium-phosphorus metabolismin HIVpatients with vitamin D deficiency. 2017:19th Eur. Congress of Endocrinology Endocrine. Abstracts. 2017;49:52.
CrossRef
- Karra E, Batterham RL. The role of gut hormones in the regulation of body weight and energy homeostasis. Mol Cell Endocrinol. 2010;316:120-8.
CrossRef
PubMed
- Clowes JA, Khosla S, Eastell R. Potential role of pancreatic and enteric hormones in regulating bone turnover. J Bone Miner Res. 2005;20:1497-506.
CrossRef
PubMed
- Cornish J, Callon KE, Bava U, Watson M, Xu X, Lin JM. Preptin, another peptide product of the pancreatic beta-cell, is osteogenic in vitro and in vivo. Am J Physiol Endocrinol Metab. 2007;292:E117-22.
CrossRef
PubMed
- Ishii S, Cauley JA, Crandall CJ, Srikanthan P, Greendale GA, Huang MH, Diabetes and femoral neck strength: findings from the hip strength across the menopausal transition study. J Clin Endocrinol Metab. 2012;97:190-7.
CrossRef
PubMed PubMedCentral
- Srikanthan P, Crandall CJ, Miller-Martinez D, Seeman TE, Greendale GA, Binkley N. Insulin resistance and bone strength: findings from the study of midlife in the United States. J Bone Miner Res, 2014;29:796-803.
CrossRef
PubMed PubMedCentral
- Gutierrez-Rojas I, Lozano D, Nuche-Berenguer B, Moreno P, Acitores A, Ramos-Alvarez I. Amylin exerts osteogenic actions with different efficacy depending on the diabetic status. Mol Cell Endocrinol. 2013;365:309-15.
CrossRef
PubMed
- Greco EA, Lenzi A, Migliaccio S. The obesity of bone. Ther Adv Endocrinol Metab. 2015; 6(6): 273-86.
CrossRef
PubMed PubMedCentral
- Mosca LN, Goldberg TB, da Silva VN, da Silva CC, Kurokawa CS, Bisi Rizzo AC, Corrente JE. Excess body fat negatively affects bone mass in adolescents. Nutrition. 2014;30:847-52.
CrossRef
PubMed
- Wong SK, Chin K-Y, Suhaimi FH, Ahmad F, Ima-Nirwana S. Effects of metabolic syndrome on bone mineral density, histomorphometry and remodelling markers in male rats. PLoS One. 2018;13(2):e0192416.
CrossRef
PubMed PubMedCentral
- Grigoryan OR, Chernova TO, Antsiferov MB. Correction of insulin resistance in postmenopausal women. Reproduct Probl. 2001;7 (4):53-61. [Russian].
- Balabolkin MI, Kreminskaya VM. Peculiarities of treatment of insulin independent diabetes mellitus. Ter Arch. 1996;10:5-11. [Russian].
- Balabolkin MI. Genetic aspects of diabetes mellitus, ed. Balabolkin MI, Dedov II. Moscow. 2000;2-9. [Russian].
CrossRef
- Tokmakova AY. The effectiveness of various methods of conservative therapy in patients with diabetic foot syndrome. Moscow. 1992;22. [Russian].
- Klockars A, Levine AS, Olszewski PK. Hypothalamic integration of the endocrine signaling related to food intake. Current Top Behav Neurosci. 2019;43:239-69.
CrossRef
PubMed
- Motyl KJ, Rosen CJ. Understanding leptin-dependent regulation of skeletal homeostasis. Biochimie. 2012; 94:2089-96.
CrossRef
PubMed PubMedCentral
- Mpalaris V, Anagnostis P, Anastasilakis AD, Goulis DG, Doumas A, Iakovou I. Serum leptin, adiponectin and ghrelin concentrations in post-menopausal women: Is there an association with bone mineral density? Maturitas. 2016;88:32-6.
CrossRef
PubMed
- Tang X, Liu G, Kang J, Hou Y, Jiang F, Yuan W, Shi J. Obesity and risk of hip fracture in adults: a metaanalysis of prospective cohort studies. PLoS One. 2013;8(4):e55077.
CrossRef
PubMed PubMedCentral
- Ginzburg MM, Kozupitsa GS. Insulin resistance syndrome. Endocrinol Probl. 1997;43(1):40-3. [Russian].
CrossRef
- Thomas T. The complex effects of leptin on bone metabolism through multiple pathways. Current Opin Pharmacol. 2004;4:295-300.
CrossRef
PubMed
- Turner RT, Kalra SP, Wong CP, Philbrick KA, Lindenmaier LB, Boghossian S, et al. Peripheral leptin regulates bone formation. J Bone Miner Res. 2013;28(1):22-34.
CrossRef
PubMed PubMedCentral
- Wang Y, Dellatore P, Douard V, Qin L, Watford M, Ferraris RP. High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice. Nutr Res. 2016;36(7):742-50.
CrossRef
PubMed PubMedCentral
- Rozhinskaya LYa, Marova EI. Osteopenic syndrome in hypothalamic-pituitary diseases. Neuroendocrinology. Clin Essays. Yaroslavl: DIA-press. 1999;423-84. [Russian].
- Wong SK, Chin K-Y, Suhaimi FH, Ahmad F, Ima-Nirwana S. The relationship between metabolic syndrome and osteoporosis: A review. Nutrients. 2016; 8(6): 347.
CrossRef
PubMed PubMedCentral
- Khashaeva TX-M, Idrisova MA, Esedova AE, Abusueva ZA, Makhtibekova PA. Bone metabolism, adipokines and obesity in postmenopausal women. Reproduct Probl. 2016;1:74-8. [Russian].
CrossRef
- Johansson H, Oden A, Lerner UH, Jutberger H, Lorentzon M, Barrett-Connor E. High serum adiponectin predicts incident fractures in elderly men: Osteoporotic Fractures in Men (MrOS) Sweden. J Bone Miner Res. 2012;27:1390-6.
CrossRef
PubMed
- Berner HS, Lyngstadaas SP, Spahr A, Monjo M, Thommesen L, Drevon CA. Adiponectin and its receptors are expressed in bone-forming cells. Bone. 2004;35:842-9.
CrossRef
PubMed
- Cao JJ. Effects of obesity on bone metabolism. J Orthop Surg Res. 2011;6:30.
CrossRef
PubMed PubMedCentral
- Jurimae J, Kums T, Jurimae T. Adipocytokine and ghrelin levels in relation to bone mineral density in physically active older women: longitudinal associations. Eur J Endocrinol. 2009;160:381-5.
CrossRef
PubMed
- Magni P, Dozio E, Galliera E, Ruscica M, Corsi MM. Molecular aspects of adipokine-bone interactions. Current Mol Med. 2010;10:522-32.
CrossRef
PubMed
- Guri AJ, Bassaganya-Riera J. Systemic effects of white adipose tissue dysregulation and obesity related inflammation. Obesity (Silver Spring). 2011;19:689-700.
CrossRef
PubMed
- Mundy GR. Osteoporosis and inflammation. Nutr Rev. 2007;65:S147-51.
CrossRef
PubMed
- Pfeilschifter J, Koditz R, Pfohl M, Schatz H. Changes in proinflammatory cytokine activity after menopause. Endocrinol Rev. 2002;23:90-119.
CrossRef
PubMed
- Gonnelli S, Caffarelli C, Nuti R. Obesity and fracture risk. Clin Cases Miner Bone Metab. 2014;11:9-14.
CrossRef
PubMed PubMedCentral
- Compston JE, Watts NB, Chapurlat R, Cooper C. Obesity is not protective against fracture in postmenopausal women: GLOW. Am J Med. 2011;124: 1043-50.
CrossRef
PubMed PubMedCentral
- Nielson CM, Srikanth P, Orwoll ES. Obesity and fracture in men and women: an epidemiologic perspective. J Bone Miner Res. 2012;27:1-10.
CrossRef
PubMed
- Reid IR. Fat and bone. Arch Biochem Biophys. 2010; 503:20-7.
CrossRef
PubMed
- Tanaka S, Kuroda T, Saito M, Shiraki M. Overweight/ obesity and underweight are both risk factors for osteoporotic fractures at different sites in Japanese postmenopausal women. Osteoporos Int. 2013;24:69-76.
CrossRef
PubMed
- Dimitri P, Bishop N, Walsh JS, Eastell R. Obesity is a risk factor for fracture in children but is protective against fracture in adults: a paradox. Bone. 2012;50:457-66.
CrossRef
PubMed
- Choudhary D, Adhikary S, Gautam J, Maurya P, Ahmad N, Kushwaha P. Detrimental effects of atherogenic and high fat diet on bone and aortic calcification rescued by an isoflavonoid Caviunin β-d-glucopyranoside. Biomed Pharmacother. 2017;92:757-71.
CrossRef
PubMed
- García-Gavilán JF, Bulló M, Canudas S, MartínezGonzález MA, Estruch R, Giardina S. Extra virgin olive oil consumption reduces the risk of osteoporotic fractures in the PREDIMED trial. Clin Nutr pii. 2017; S0261- 5614(17):30006-7.
- Minematsu A, Nishii Y, Sakatab S. High-fat/high-sucrose diet results in higher bone mass in aged rats. Bone. 2018;8:18-24.
CrossRef
PubMed PubMedCentral
Yarrow JF, Toklu HZ, Balaez A, Phillips EG. Fructose consumption does not worsen bone deficits resulting from high-fat feeding in young male rats. Bone. 2016;85:99-
CrossRef
PubMed PubMedCentral
- Yan L, Graef GL, Nielsen FH, Johnson LK, Cao J. Soy protein is beneficial but high-fat diet and voluntary running are detrimental to bone structure in mice. Nutr Res. 2015;35(6):523-31.
CrossRef
PubMed
Lecka-Czernik B, Stechschulte LA, Czernik PJ, Dowling AR. High bone mass in adult mice with diet-induced obesity results from a combination of initial increase in bone mass followed by attenuation in bone formation; implications for high bone mass and decreased bone quality in obesity. Mol Cell Endocrinol. 2015;410:35-41;
CrossRef
PubMed
- Doucette CR, Horowitz MC, Berry R, MacDougald OA, Anunciado-Koza R, Koza RA, Rosen CJ. A high fat diet increases bone marrow adipose tissue (MAT) but does not alter trabecular or cortical bone mass in C57BL/6J mice. J Cell Physiol. 2015;230(9):2032-7.
CrossRef
PubMed PubMedCentral
- Markovic TP, Natoli SJ. Paradoxical nutritional deficiency in overweight and obesity: the importance of nutrient density. Med J. 2009;190:149-51.
CrossRef
PubMed
- Grethen E, Hill KM, Jones R, Cacucci BM, Gupta CE. Serum leptin, parathyroid hormone, 1,25-dihydroxyvitamin D, fibroblast growth factor 23, bone alkaline phosphatase, and sclerostin relationships in obesity. J Clin Endocrinol Metab. 2012;97:1655-62.
CrossRef
PubMed PubMedCentral
- Stein EM, Strain G, Sinha N, Ortiz D. Vitamin D insufficiency prior to bariatric surgery: risk factors and a pilot treatment study. Clin Endocrinol. 2009;71:176-83.
CrossRef
PubMed PubMedCentral
- Hsu Y-H, Venners SA, Terwedow HA, Feng Y. Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr. 2006;83:146-54.
CrossRef
PubMed
- Shu L, Beier E, Sheu T, Zhang H. High-fat diet causes bone loss in young mice by promoting osteoclastogenesis through alteration of the bone marrow environment. Calcif Tissue Int. 2015 Apr; 96(4): 313-23.
CrossRef
PubMed PubMedCentral
- Felice JI, Gangoiti MV, Molinuevo MS, McCarthy AD, Cortizo AM. Effects of a metabolic syndrome induced by a fructose-rich diet on bone metabolism in rats. Metabolism. 2014;63(2):296-305.
CrossRef
PubMed
- Felice JI, Schurman L, McCarthy AD, Sedlinsky C, Aguirre JI, Cortizo AM. Effects of fructose-induced metabolic syndrome on rat skeletal cells and tissue, and their responses to metformin treatment. Diabetes Res Clin Pract. 2017;126:202-13.
CrossRef
PubMed
- Li Tian, Xijie Yu Fat, Sugar, and bone health: A complex relationship. Nutrients. 2017;9(5):506.
CrossRef
PubMed PubMedCentral
- Lavet C, Martin A, Linossier MT, Vanden Bossche A Laroche N, Thomas M. Fat and sucrose intake induces obesity-related bone metabolism disturbances: Kinetic and reversibility studies in growing and adult rats. J Bone Min Res. 2016;31(1):98-115.
CrossRef
PubMed
- Minematsu A, Hanaoka T, Takada Y, Okuda S. Femoral bone structure in Otsuka Long-Evans Tokushima Fatty rats. Osteoporos Sarcopen. 2016;2:25-9.
CrossRef
PubMed PubMedCentral
- Minematsu A, Hanaoka T, Takeshita D, Takada Y. Long-term wheel-running can prevent deterioration of bone properties in diabetes mellitus model rats. J. Musculoskelet. Neuronal Interact. 2017;17:433-43.
- Dawson-Hughes B, Harris SS, Lichtenstein AH, Dolnikowski G, Palermo NJ, Rasmussen H. Dietary fat increases vitamin D-3 absorption. J Acad Nutr Diet. 2015;115:225-30.
CrossRef
PubMed
- Macri EV, Gonzales Chaves MM, Rodriguez PN. High-fat diets affect energy and bone metabolism in growing rats. Eur J Nutr. 2012;51(4):399-406.
CrossRef
PubMed
|
|
|
|
|
|
|