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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2021; 67(2): 53-66


THE ROLE OF HYPOXIA IN THE DEVELOPMENT OF SOME PATHOLOGICAL CONDITIONS AND MALIGNANT TUMORS

N.O. Bogdanova, N.H. Pogorela, E.A. Lukyanetz

    O.O. Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz67.02.053

Abstract

Hypoxia, which could be defined as the level of oxygen tension in the body that is below the normal physiological value, is a process that is often observed in several diseases and occurs in most malignant tumors. On the other hand, in hypoxia several pathological conditions could occur, which could be caused by external and internal factors. During carcinogenesis, hypoxia may promote metastasis and an unfavorable prognosis. When infected with COVID-19, there is a «silent hypoxia», which could asymptomatically destroy the body. The review is devoted to hypoxia’s role in the development of some pathological conditions and malignant tumors.

Keywords: hypoxia; carcinogenesis; exogenous hypoxia; endogenous hypoxia

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