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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2021; 67(2): 31-36


THE CONTENT OF INTERLEUKIN-10 IN THE SUPERNATANTS OF IMMUNOCOMPETENT CELLS IN PATIENTS WITH VARIOUS FORMS OF CORONARY HEART DISEASE

N.O. Ryzhkova1, T.I. Gavrilenko1, L.V. Yakushko1, O.M. Parkhomenko1, N.V. Dovgan1, O.V. Dovgan1, O.M. Lomakovsky1, Yu.Y. Babchuk2, S.М. Babiy2

  1. State Institution National Scientific Center «M.D. Strazhesko Institute of Cardiology National Academy of Medical Sciences of Ukraine», Kyiv, Ukraine
  2. Taras Shevchenko National University of Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz67.02.031

Abstract

198 patients with coronary heart disease (stable and unstable angina- UA, acute myocardial infarction-AMI) were examined. The content of interleukin-10 (IL-10) in the supernatants of immunocompetent cells was determined at hospitalization. In patients with unstable angina and myocardial infarction it was also measured on the 7th day of the treatment. A wide range of the indicators was revealed when patients were admitted to hospital. In this regard, the subjects were divided into 2 subgroups: A - with a low content of IL-10 in mononuclear cells (UA - 58.1, AMI - 75.4%), B - with a normal or high content of this cytokine in these cells. In the dynamics of treatment, the indicators in mononuclear cells change depending on the initial value of the concentration of IL-10: its low content increases, high - decreases. On the 7th day of treatment, the content of the studied factor in these cells became almost the same in all subgroups. A low level of the anti-inflammatory cytokine IL-10 at the beginning of the disease is probably a pathogenetic link and a predictor of acute coronary events.

Keywords: coronary heart disease; immunocompetent cells; cytokines; interleukin-10.

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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2022.