INFLUENCE OF MICRORNA MIR-101 ON THE STRUCTURAL AND FUNCTIONAL ORGANIZATION OF THE WAKE-SLEEP CYCLE UNDER AMYLOIDOSIS IN RATS
V.V. Geyko, N.A. Levicheva, V.V. Sokolik
SI «Institute of Neurology, Psychiatry and Narcology of National Academy of Medical Sciences of Ukraine», Ukraine
The effects of transnasal introduction of microRNA (miR-101)
in liposomal form on the structural and functional organization
of sleep were investigated under conditions of modeling
Alzheimer's disease in rats of late adulthood. It is shown that
in experimental amyloidosis, course administration of miR101 promotes a significant (22-fold) increase in the duration
of the deep slow-wave phase and a two-fold increase in the
production of paradoxical sleep that is accompanied by a
normalization of the rhythmic organization of the wake-sleep
cycle and reflects the positive direction of these effects on its
qualitative characteristics, probably, due to the inhibitory effect
on the synthesis of the precursor of β-amyloid peptides. The
results obtained may indicate the prospects for further study
of the therapeutic potential of miR-101.
wake-sleep cycle; modeling of Alzheimer’s disease; β-amyloid peptide; miR-101; transnasal introduction
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