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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2021; 67(1): 37-43

INFLUENCE OF MICRORNA MIR-101 ON THE STRUCTURAL AND FUNCTIONAL ORGANIZATION OF THE WAKE-SLEEP CYCLE UNDER AMYLOIDOSIS IN RATS

V.V. Geyko, N.A. Levicheva, V.V. Sokolik

    SI «Institute of Neurology, Psychiatry and Narcology of National Academy of Medical Sciences of Ukraine», Ukraine
DOI: https://doi.org/10.15407/fz67.01.037


Abstract

The effects of transnasal introduction of microRNA (miR-101) in liposomal form on the structural and functional organization of sleep were investigated under conditions of modeling Alzheimer's disease in rats of late adulthood. It is shown that in experimental amyloidosis, course administration of miR101 promotes a significant (22-fold) increase in the duration of the deep slow-wave phase and a two-fold increase in the production of paradoxical sleep that is accompanied by a normalization of the rhythmic organization of the wake-sleep cycle and reflects the positive direction of these effects on its qualitative characteristics, probably, due to the inhibitory effect on the synthesis of the precursor of β-amyloid peptides. The results obtained may indicate the prospects for further study of the therapeutic potential of miR-101.

Keywords: wake-sleep cycle; modeling of Alzheimer’s disease; β-amyloid peptide; miR-101; transnasal introduction

Full text: (PDF, in Ukrainian)

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