Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2021; 67(1): 24-28


A.O. Nastenko, H.E. Purnyn, S.A, Fedulova, M.S. Veselovsky

  1. Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine


Excitatory postsynaptic potentials (EPSP) were recorded from the superior cervical ganglion neurons (SCG) in the rats with experimental streptozotocininduced diabetes (ESD). EPSP was inducted by electrical stimulation of the cervical sympathetic trunk. It was founded that the average value of the EPSP time constant decay in the rats with ESD was 15% higher. At the same time, the amplitudes of EPSP of SCG neurons and the hexamethonium blocking effect in the rats with ESD on 30th day after streptozotocin injection didn’t differ significantly from those in control rats. This may indicate specific functional disorders associated as with steady-state elevated blood glucose level in rats as SCG neurons nicotinic cholinergic receptors.

Keywords: superior cervical ganglion; streptozotocin-induced diabetes; hexamethonium


  1. Campanucci V, Krishnaswamy A, Cooper E. Diabetes depresses synaptic transmission in sympathetic ganglia by inactivating nAChRs through a conserved intracellular cysteine residue. Neuron. 2010 Jun 24;66(6):827-34. CrossRef PubMed
  2. Schmidt RE, Plurad SB, Parvin CA, Roth KA. Effect of diabetes and aging on human sympathetic autonomic ganglia. Am J Pathol. 1993 Jul;143(1):143-53.
  3. Lenzen S. Alloxan and streptozotocin diabetes. Diabetologia. 2008 Feb;51(2):216-26. CrossRef PubMed
  4. Skok VI, Ivanov AYa. Natural activity of vegetative ganglia. Kiev: Nauk Dumka; 1989. [Russian].
  5. Li C, Horn JP. Physiological classification of sympathetic neurons in the rat superior cervical ganglion. J Neurophysiol. 2006 Jan;95(1):187-95. CrossRef PubMed
  6. Silva-Dos-Santos NM, Oliveira-Abreu K, Moreira-Junior L, Santos-Nascimento TD, Silva-Alves KSD, Coelhode-Souza AN, et al. Diabetes mellitus alters electrophysiological properties in neurons of superior cervical ganglion of rats. Brain Res. 2020 Feb;1729:1465-99. CrossRef PubMed
  7. Purnyn H, Rikhalsky O, Fedulova S, Veselovsky N. Transmission pathways in the rat superior cervical ganglion. Neurophysiology. 2007 Jul;39(4);347-9. CrossRef

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.