|
|
|
|
|
|
SYNAPTIC RESPONSES OF SUPERIOR CERVICAL GANGLION NEURONS OF RATS WITH EXPERIMENTAL DIABETES MELLITUS
A.O. Nastenko, H.E. Purnyn, S.A, Fedulova, M.S. Veselovsky
- Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz67.01.024
![](/images/cite.png)
Abstract
Excitatory postsynaptic potentials (EPSP) were recorded
from the superior cervical ganglion neurons (SCG) in the rats with experimental streptozotocininduced diabetes (ESD).
EPSP was inducted by electrical stimulation of the cervical
sympathetic trunk. It was founded that the average value of
the EPSP time constant decay in the rats with ESD was 15%
higher. At the same time, the amplitudes of EPSP of SCG
neurons and the hexamethonium blocking effect in the rats
with ESD on 30th day after streptozotocin injection didn’t
differ significantly from those in control rats. This may indicate
specific functional disorders associated as with steady-state
elevated blood glucose level in rats as SCG neurons nicotinic
cholinergic receptors.
Keywords:
superior cervical ganglion; streptozotocin-induced diabetes; hexamethonium
References
- Campanucci V, Krishnaswamy A, Cooper E. Diabetes depresses synaptic transmission in sympathetic ganglia by inactivating nAChRs through a conserved intracellular cysteine residue. Neuron. 2010 Jun 24;66(6):827-34.
CrossRef
PubMed
- Schmidt RE, Plurad SB, Parvin CA, Roth KA. Effect of diabetes and aging on human sympathetic autonomic ganglia. Am J Pathol. 1993 Jul;143(1):143-53.
- Lenzen S. Alloxan and streptozotocin diabetes. Diabetologia. 2008 Feb;51(2):216-26.
CrossRef
PubMed
- Skok VI, Ivanov AYa. Natural activity of vegetative ganglia. Kiev: Nauk Dumka; 1989. [Russian].
- Li C, Horn JP. Physiological classification of sympathetic neurons in the rat superior cervical ganglion. J Neurophysiol. 2006 Jan;95(1):187-95.
CrossRef
PubMed
- Silva-Dos-Santos NM, Oliveira-Abreu K, Moreira-Junior L, Santos-Nascimento TD, Silva-Alves KSD, Coelhode-Souza AN, et al. Diabetes mellitus alters electrophysiological properties in neurons of superior cervical ganglion of rats. Brain Res. 2020 Feb;1729:1465-99.
CrossRef
PubMed
- Purnyn H, Rikhalsky O, Fedulova S, Veselovsky N. Transmission pathways in the rat superior cervical ganglion. Neurophysiology. 2007 Jul;39(4);347-9.
CrossRef
|
|
|
|
|
|
|
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
|
|