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SYNAPTIC RESPONSES OF SUPERIOR CERVICAL GANGLION NEURONS OF RATS WITH EXPERIMENTAL DIABETES MELLITUS
A.O. Nastenko, H.E. Purnyn, S.A, Fedulova, M.S. Veselovsky
- Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz67.01.024
Abstract
Excitatory postsynaptic potentials (EPSP) were recorded
from the superior cervical ganglion neurons (SCG) in the rats with experimental streptozotocininduced diabetes (ESD).
EPSP was inducted by electrical stimulation of the cervical
sympathetic trunk. It was founded that the average value of
the EPSP time constant decay in the rats with ESD was 15%
higher. At the same time, the amplitudes of EPSP of SCG
neurons and the hexamethonium blocking effect in the rats
with ESD on 30th day after streptozotocin injection didn’t
differ significantly from those in control rats. This may indicate
specific functional disorders associated as with steady-state
elevated blood glucose level in rats as SCG neurons nicotinic
cholinergic receptors.
Keywords:
superior cervical ganglion; streptozotocin-induced diabetes; hexamethonium
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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
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