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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2020; 66(6): 97-103

SIRT1 IS A REGULATOR OF AUTOPHAGY IN INTESTINAL CELLS

A.P. Lytvynenko, T.Yu. Voznesenskaya, R.I. Janchij

    O.O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz66.06.097


Abstract

Sirtuin1 (SIRT1) – is NAD(+)-dependent deacetylase, which possess significant roles in apoptosis, cell cycle, cell senescence, mitochondrial function, and metabolism. SIRT1 is widely expressed in all intestinal epithelial cells and is an important regulator of autophagy. Macroautophagy plays a key role in maintaining intestinal homeostasis, in regulating the interaction between gut microbiota and innate and adaptive immunity, the integrity of the epithelial barrier and the immune response of the mucous membrane. Nowadays SIRT-dependent mechanisms of autophagy of intestinal cells remain not fully structured and studied. Therefore, the aim of the current review is collection, analysis and synthesis of literature data of the role of SIRT1 in the regulation of autophagy in intestinal cells.

Keywords: sirtuin1; autophagy; intestinal cells.

Full text: (PDF, in Ukrainian)

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