SIRT1 IS A REGULATOR OF AUTOPHAGY IN INTESTINAL CELLS
A.P. Lytvynenko, T.Yu. Voznesenskaya, R.I. Janchij
O.O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz66.06.097
Abstract
Sirtuin1 (SIRT1) – is NAD(+)-dependent deacetylase, which
possess significant roles in apoptosis, cell cycle, cell senescence, mitochondrial function, and metabolism. SIRT1 is
widely expressed in all intestinal epithelial cells and is an
important regulator of autophagy. Macroautophagy plays a
key role in maintaining intestinal homeostasis, in regulating
the interaction between gut microbiota and innate and adaptive
immunity, the integrity of the epithelial barrier and the immune
response of the mucous membrane. Nowadays SIRT-dependent
mechanisms of autophagy of intestinal cells remain not fully
structured and studied. Therefore, the aim of the current review
is collection, analysis and synthesis of literature data of the
role of SIRT1 in the regulation of autophagy in intestinal cells.
Keywords:
sirtuin1; autophagy; intestinal cells.
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