THE ROLE OF BETA-AMYLOID IN NORM AND AT ALZHEIMER`S DISEASE
Yu. N. Tyshchenko, E.A. Lukyanetz
O.O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz66.06.088
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Abstract
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive cognitive impairment and memory
loss. The pathogenesis of AD is complex, depends on many
factors, and has not yet been fully studied. Extracellular deposits of amyloid-β (Aβ) peptide in the form of senile plaques, the
formation of intracellular neurofibrillary tangles, and massive
neuronal loss are considered as the main pathological signs
of AD. However, recently there have been many data that
indicate other pathways involved in the pathogenesis of AD.
This review aims to analyze the existing data on the physiological role of Aβ in the brain under normal conditions and
its pathological role in Alzheimer’s disease.
Keywords:
amyloid-β; Alzheimer’s disease; cognitive functions; neurodegeneration.
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