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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2020; 66(5): 73-84


I. Prudnikov1, V. Tsyvkin1, A. Smirnov1, I. Pristash1, M. Syrko2

  1. Bogomoletz Institute of Physiology of NAS of Ukraine, Kyiv, Ukraine
  2. Taras Shevchenko National University of Kyiv, Kyiv, Ukraine


Little-known to a wide range of specialists details of the functioning of one of the main participants in cellular metabolism – a complex of neutral proteases with their regulators, which is called “proteasome” – are observed in this paper. The review analyzes the works of recent years devoted to the study of the participation of proteasomes in intercellular signaling and catabolism of regulatory and signaling proteins in the extracellular space.

Keywords: exosome; protease; proteasome; signalization.


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