THE EFFECT OF PROTEASE-ACTIVATED RECEPTORS 1 INHIBITION ON DEPRESSIVE-LIKE BEHAVIOR IN THE LATENT STAGE OF FORMATION OF TEMPORAL LOBE EPILEPSY
М. Semenikhina, M. Fedoryuk, R. Bogovik
O.O.Bogomoletz Institute of Physiology of NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz66.05.017
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Abstract
Here we investigate the effect of pharmacological blockade
of protease-activated receptors 1 (PAR1) on depressive-like
behavioral impairments following status epilepticus (SE). Behavioral tests were performed during the latent stage of formation of temporal lobe epilepsy two weeks after SE induced using
lithium-pilocarpine model. The PAR1 blocker (SCH 79797) was
injected for 10 days after SE. The results indicate a partial normalization of depressive-like behavior in the forced swim test:
the climbing time was 180 s after PAR1 inhibition, and
87 s after SE). We also observed behavioral normalization
after PAR1 inhibition in the sucrose test. PAR1 inhibition led to
the normalization of climbing time in the forced swim test, as
well as normalized the behavior in the sucrose preference test.
At the same time, the swimming time in the forced swim test
decreased due to the PAR1 inhibition compared to the control
group, while the floating time increased.
Keywords:
status epilepticus; latent stage of epilepsy formation; protease-activated receptors 1; PAR1; depression.
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