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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2020; 66(4): 64-71


EFFECT OF N-ACETYLCARNOSINE CONTAINED EYE DROP ON CATECHOLAMINE-INDUCED MORPHOFUNCTIONAL DAMAGE IN RAT RETINA

V.V. Sanin1, A.I. Yakovets1, K.V. Rozova2, Yu.P. Korkach2, Yu.V. Goshovska2, I.V. Shargorodska3, S.O. Rykov3

  1. Kyiv City Clinical Ophthalmic Hospital Center for Eye Microsurgery, Kyiv, Ukraine
  2. O.O.Bogomoletz Institute of Physiology, NAS of Ukraine, Kyiv, Ukraine
  3. Shupyk National Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz66.04.064

Abstract

The effects of N-acetylcarnosine (NAC)-contained eye drop ‘Clarastil’ on a model of adrenaline-induced high intraocular pressure (IOP) in Wistar rats were studied. The retina ultrastructure and markers of oxidative stress have been studied. NAC was found to have no significant effect on edema in the retinal ultrastructure, did not reduce endothelial thickening and histogemic barrier, and accordingly did not affect the value of IOP after prolonged adrenaline administration. However, the introduction of the eye drop prevented the swelling of the mitochondria, the formation of vacuolated crystals and probably stimulated energy production as a compensatory mechanism under conditions of hypercatecholemia. In addition, NAC significantly reduced adrenaline-induced overproduction of reactive oxygen species and lipid peroxidation products in eye tissues, indicating its antioxidant effect.

Keywords: retina; adrenaline; intraocular pressure; oxidative stress; mitochondria, N-acetylcarnosine, glaucoma.

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