EFFECT OF N-ACETYLCARNOSINE CONTAINED EYE DROP ON CATECHOLAMINE-INDUCED MORPHOFUNCTIONAL DAMAGE IN RAT RETINA
V.V. Sanin1, A.I. Yakovets1, K.V. Rozova2, Yu.P. Korkach2, Yu.V. Goshovska2, I.V. Shargorodska3, S.O. Rykov3
- Kyiv City Clinical Ophthalmic Hospital Center for Eye Microsurgery, Kyiv, Ukraine
- O.O.Bogomoletz Institute of Physiology, NAS of Ukraine, Kyiv, Ukraine
- Shupyk National Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz66.04.064
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Abstract
The effects of N-acetylcarnosine (NAC)-contained eye
drop ‘Clarastil’ on a model of adrenaline-induced high
intraocular pressure (IOP) in Wistar rats were studied.
The retina ultrastructure and markers of oxidative stress
have been studied. NAC was found to have no significant
effect on edema in the retinal ultrastructure, did not reduce
endothelial thickening and histogemic barrier, and accordingly
did not affect the value of IOP after prolonged adrenaline
administration. However, the introduction of the eye drop
prevented the swelling of the mitochondria, the formation
of vacuolated crystals and probably stimulated energy
production as a compensatory mechanism under conditions
of hypercatecholemia. In addition, NAC significantly reduced
adrenaline-induced overproduction of reactive oxygen species
and lipid peroxidation products in eye tissues, indicating its
antioxidant effect.
Keywords:
retina; adrenaline; intraocular pressure; oxidative stress; mitochondria, N-acetylcarnosine, glaucoma.
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