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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2020; 66(4): 55-63


O.M. Kravchuk1, Yu.V. Goshovska2, Yu.P. Korkach2, V.F. Sagach2

  1. Kozyatyn Central District Hospital of Kozyatyn District Council Vinnitsia region, Ukraine
  2. O.O.Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine


Arterial hypertension (AH) is a multifactorial disease that is accompanied by the development of oxidative-nitrosative stress and insufficient production of hydrogen sulfide (H2S). We hypothesized that garlic bio supplement Full Spectrum Garlic (Swanson Health Product, USA) may be used as a potential H2S donor in treatment of AH in patients. The aim was to study the effect of garlic on blood pressure, ROS generation and cNOS/iNOS activity, biochemical in male 28-39 years old patients with grade II AH. It was found that 10 days of standard antihypertensive therapy (adrenoblockers, ACE inhibitors) with 30 days of garlic supplementation reduced mean systolic and diastolic pressures by 9 and 8 mm Hg respectively. Positive effects of garlic consumption on hemodynamic parameters were observed: enddiastolic volume increased by 8% and peripheral vascular resistance decreased by 11,3% . In the blood plasma of patients, H2S levels increased by 43,6% , the production of ROS and the content of lipid peroxidation products decreased significantly. It is important that the cNOS activity was increased by 130% and iNOS activity decreased by 38,3%. No significant changes in cholesterol, urea, creatinine, glucose, as well as erythrocyte parameters were observed, which indicates the tolerance of the garlic supplements. Thus, the hypotonic effect of garlic is realized by increasing endogenous H2S in plasma, improving endothelium-dependent relaxation of blood vessels and reducing the manifestations of oxidative stress, which makes it promising to use it in the complex therapy of hypertension.

Keywords: arterial hypertension; peripheral vascular resistance; garlic; hydrogen sulfide; nitric oxide; oxidative stress.


  1. Atlas SA. The renin-angiotensin aldosterone system: Pathophysiological Role and Pharmacologic Inhibition. J Manag Care Pharm. 2007 Oct;13(8 Supp B):9-20. CrossRef PubMed
  2. Wright JM, Musini VM, Gill R. First-line drugs for hypertension. Cochrane Database Syst Rev. 2018 Apr 18. CrossRef PubMedCentral
  3. Richards TR, Tobe SW. Combining Other Antihypertensive Drugs With β-Blockers in Hypertension: A Focus on Safety and Tolerability. Can J Cardiol. 2014 May;30(5):S42-6. CrossRef PubMed
  4. Coats A, Jain S. Protective effects of nebivolol from oxidative stress to prevent hypertension-related target organ damage. J Hum Hypertens. 2017 Jun 2;31(6):376-81. CrossRef PubMed PubMedCentral
  5. Sahach V, Baziliuk O, Kotsiuruba A, Buzhanevich O. Disturbance of endothelium-dependent vascular responses, arginase and NO-synthase pathways of L-arginine metabolism at spontaneously hypertensive rats. Fiziol Zh. 2000;46(3):3-13.
  6. Zepeda RJ, Castillo R, Rodrigo R, Prieto JC, Aramburu I, Brugere S, et al. Effect of Carvedilol and Nebivolol on Oxidative Stress-related Parameters and Endothelial Function in Patients with Essential Hypertension. Basic Clin Pharmacol Toxicol. 2012 Nov;111(5):309-16. CrossRef PubMed
  7. Pronko TP, Zinchuk V V. Effect of nebivolol on blood oxygen transport indices and endothelial dysfunction in patients with arterial hypertension. Clin Physiol Funct Imaging. 2009 May;29(3):170-6. CrossRef PubMed
  8. Ng HH, Yildiz GS, Ku JM, Miller AA, Woodman OL, Hart JL. Chronic NaHS treatment decreases oxidative stress and improves endothelial function in diabetic mice. Diabetes Vascul Dis Res. 2017 May;14(3):246-53. CrossRef PubMed
  9. Ozatik FY, Teksen Y, Kadioglu E, Ozatik O, Bayat Z. Effects of hydrogen sulfide on acetaminophen-induced acute renal toxicity in rats. Int Urol Nephrol. 2019 Apr 2;51(4):745-54. CrossRef PubMed
  10. Shymans'ka T, Hoshovs'ka I, Semenikhina O, Sahach V. Effect of hydrogen sulfide on isolated rat heart reaction under volume load and ischemia-reperfusion. Fiziol Zh. 2012;58(6):57-66. CrossRef PubMed
  11. Mys LA, Strutynska NA, Goshovska YV, Sagach VF. Stimulation of the endogenous hydrogen sulfide synthesis suppresses oxidative-nitrosative stress and restores endothelial-dependent vasorelaxation in old rats. Can J Physiol Pharmacol. 2020 May;98(5):275-81. CrossRef PubMed
  12. Drachuk KO, Kotsjuruba AV, Sagach VF. Hydrogen sulfide donor, NAHS, recovers constitutive NO synthesis and endothelium-depended relaxation of isolated aorta in old rats. Fiziol Zh. 2015 Oct 30;61(6):3-10. CrossRef PubMed
  13. Bradley JM, Organ CL, Lefer DJ. Garlic-Derived Organic Polysulfides and Myocardial Protection. J Nutr. 2016 Feb 1;146(2):403S-409S. CrossRef PubMed PubMedCentral
  14. Ried K, Travica N, Sali A. The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial. Integr Blood Press Control. 2016 Jan;9. CrossRef PubMed PubMedCentral
  15. Yagdi E, Cerella C, Dicato M, Diederich M. Garlic-derived natural polysulfanes as hydrogen sulfide donors: Friend or foe? Food Chem Toxicol. 2016 Sep;95:219-33. CrossRef PubMed
  16. DeLeon ER, Gao Y, Huang E, Olson KR. Garlic oil polysulfides: H2S- and O2-independent prooxidants in buffer and antioxidants in cells. Am J Physiol Integr Comp Physiol. 2016 Jun 1;310(11):R1212-25. CrossRef PubMed PubMedCentral
  17. Al-Qattan KK, Thomson M, Ali M. Garlic extract increases non-clipped kidney tubular natriuresis and diuresis in the 2-kidney, 1-clip rat model: Significance in hypertension. Pathophysiology. 2017 Dec;24(4):317-25. CrossRef PubMed
  18. Dhawan V, Jain S. Garlic supplementation prevents oxidative DNA damage in essential hypertension. Mol Cell Biochem. 2005 Jul;275(1-2):85-94. CrossRef PubMed
  19. Yan H, Du J, Tang C. The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats. Biochem Biophys Res Commun. 2004 Jan;313(1):22-7. CrossRef PubMed
  20. Kuthan H, Ullrich V, Estabrook RW. A quantitative test for superoxide radicals produced in biological systems. Biochem J. 1982 Jun 1;203(3):551-8. CrossRef PubMed PubMedCentral

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