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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2020; 66(2-3): 93-100


EXPERIMENTAL MODELS IN THE STUDY OF THE MECHANISMS AND CONSEQUENCES OF EPILEPTIC SEIZURES IN NEONATAL PERIOD OF LIFE

A. Romanov, E. Isaeva

  1. Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz66.2-3.093

Abstract

The neonatal period is associated with a high risk of epileptic seizures and epilepsy development. Seizures in early life can significantly interfere with a normal CNS development, cause neural cell death, and negatively impact of the coordination and arrangement of synaptic connections during ontogenesis, which could result in a range of chronic cognitive and behavioral deficits. The negative effects of epileptic seizures on the brain function largely depends on the nature of provoking factors, so to study the cellular and molecular mechanisms underlying development of epileptic seizures in the neonatal period and their consequences, various experimental models have been developed to reproduce pathological changes in animals, caused by specific stimuli. This review highlights the most common experimental models of seizures and epilepsy in the neonatal period, discusses their strength and limitations, and examines pathological, behavioral and neurophysiological similarities and differences between animal models and the equivalent human condition.

Keywords: epilepsy; animal models; aging.

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