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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2020; 66(2-3): 83-92


O.N. Sulaieva1, D.O. Shapochka1, O.E. Stakhovskiy2, O.Ya. Zahoruiko1, N.V. Stefiniv1, T.A. Stepanova1, D.A. Rozhkova1

  1. Medical Laboratory CSD, Kyiv, Ukraine
  2. National Institute of Cancer, Kyiv, Ukraine


The review is dedicated to the analysis of key molecular genetic alterations associated with the development and progression of bladder cancer (BC). BC is a disease with a complex genetic landscape and heterogeneous molecular, histological and clinical characteristics. BC is characterized by genetic alterations affecting cell cycle regulators (oncogenes and tumor suppressor genes), receptor tyrosine kinases and downstream signaling pathways, chromatin remodeling regulators, including histone-modifying genes and SWI/ SNF components of the nucleosome remodeling complex, transcription regulators as well as DNA repair enzymes. Investigation of genetic landscape has played a key role in the development of the concept of BC molecular subtyping and personalized therapy.

Keywords: bladder cancer; genomics; genetic alterations; personalized therapy.


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