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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2020; 66(2-3): 13-20

ANALYSIS OF ASSOCIATION BETWEEN LONG NON-CODING RNA ANRIL GENE RS4977574 POLYMORPHISM AND BLADDER CANCER DEVELOPMENT

A. D. Volkogon, O.A. Obukhova, V. Yu. Harbuzova, A.V. Ataman

    Sumy State University, Ukraine
DOI: https://doi.org/10.15407/fz66.2-3.013


Abstract

Herein the results of long non-coding RNA ANRIL gene rs4977574 polymorphism determination in 241 representatives of Ukrainian population: 141 patients with transitional cell carcinoma of urinary bladder (TCCUB) and 100 patients without oncological history (control group) have been submitted. Genotyping was performed using real-time polymerase chain reaction (Real-time PCR) method. The genotypes frequency of ANRIL gene rs4977574 locus in general group was not significantly different between control subjects and TCCUB patients. Stratified analysis revealed no significant difference between women, men, nonsmokers and smokers. The results of binary logistic regression showed no association between rs4977574 site and TCCUB risk in general group. Significant association was not found even after adjusting for gender, age, body mass index, and smoking habit. Analysis in male, female subjects, in individuals without and with smoking habit demonstrated similar results. Thus, no link between ANRIL gene rs4977574 polymorphism and TCCUB development in Ukrainian population was established.

Keywords: long non-coding RNA; ANRIL; single-nucleotide polymorphism; bladder cancer.

Full text: (PDF, in Ukrainian)

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