EFFECT OF ENDOTHELIAL MONOCYTE-ACTIVATING POLYPEPTIDE-II ON ENDOTHELIUM-DEPENDENT VASCULAR RELAXATION DURING AGING
K.O. Drachuk1, Yu.P. Korkach1, N.A. Dorofeyeva1, O.I. Kornelyuk2, V.F. Sagach1
- O.O. Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
- Institute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz65.06.038
Abstract
We studied the effect of endothelial monocyte-activating
polypeptide-II (EMAP II) on endothelium-dependent vascular
relaxation in old rats. It was found a violation of endotheliumdependent
aorta relaxation in these animals, the average value
of its amplitude was 7.5±1.4% compared with 64.9±3.5% in
healthy adult rats. EMAP II significantly improved endothelium-dependent
relaxation in old animals, the average value of
its amplitude increased to 66.6±6.8%. This effect was due to
oxidative stress inhibition, cNOS recoupling and increasing
of constitutive NO-synthesis; thus, index of cNOS coupling/
uncoupling increased by 51 times and cNOS activity increased
by 2.8 times.
Keywords:
endothelial monocyte-activating polypeptide-II; aging; endothelium-dependent relaxation; oxidative stress; nitric oxide
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