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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(6): 38-42


EFFECT OF ENDOTHELIAL MONOCYTE-ACTIVATING POLYPEPTIDE-II ON ENDOTHELIUM-DEPENDENT VASCULAR RELAXATION DURING AGING

K.O. Drachuk1, Yu.P. Korkach1, N.A. Dorofeyeva1, O.I. Kornelyuk2, V.F. Sagach1

  1. O.O. Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
  2. Institute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz65.06.038

Abstract

We studied the effect of endothelial monocyte-activating polypeptide-II (EMAP II) on endothelium-dependent vascular relaxation in old rats. It was found a violation of endotheliumdependent aorta relaxation in these animals, the average value of its amplitude was 7.5±1.4% compared with 64.9±3.5% in healthy adult rats. EMAP II significantly improved endothelium-dependent relaxation in old animals, the average value of its amplitude increased to 66.6±6.8%. This effect was due to oxidative stress inhibition, cNOS recoupling and increasing of constitutive NO-synthesis; thus, index of cNOS coupling/ uncoupling increased by 51 times and cNOS activity increased by 2.8 times.

Keywords: endothelial monocyte-activating polypeptide-II; aging; endothelium-dependent relaxation; oxidative stress; nitric oxide

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