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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2002; 48(1): 62-66


Influence of restored 5α-androgens on puberty in the female rats

L.B. Litvinova V.M. Vakula

    V. Danilevsky Institute of Endocrine PathologyProblems



The female rats at a prepubertal period were introduced to the restored 5α-androgens, namely: 5α-dihydrotestosterone (DHT), 5α-androstane-3α, 17β-diol (3α-diol) or 5α-androstane-3α, 17β-diol (3β-diol) in the dose of 5 mg/100 g. Both DHT and 3α-diol have been determined to induce the vaginal opening as the initial stage of puberty. Stimulation of the puberty in those rats was followed with an activation of both endocrine and generative functions of the ovaries. DHT inhibited the gonadotrophic activity of the hypophysis that delayed the ovulation as the final stage of puberty. The DHT metabolite 3α-diol hastened the first ovulation, while 3β-diol did not influence the pace of the puberty. The stimulating effect of DHT at the initial stage of the pubescence in the female rats has been suggested to be due to its convertion into 3α-diol which is likely to be one of the key factors in the pubescence control in rats.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2025.